| Identification | Back Directory | [Name]
H2N-PEG4-tBu | [CAS]
581065-95-4 | [Synonyms]
H2N-PEG4-tBu
Amino-PEG4-Boc
Amino-PEG4-COOtBu
NH2-PEG4-CH2CH2COOtBu
H2N-PEG4-CH2CH2COOtBu
NH2-PEG4-(CH2)2COOtBu
H?N-PEG?-CH?CH?COOtBu
Amino-PEG4-t-butyl ester
Amino-dPEG4-t-butyl ester
H2N-PEG4-CH2CH2-t-butylester
AMINO-PEG4-PROPANOIC ACID T-BUTYL ESTER
tert-Butyl 15-aMino-4,7,10,13-tetraoxapentadecanoate
tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate
tert-Butyl 1-Amino-3,6,9,12-tetraoxa-15-pentadecanoate
15-Amino-4,7,10,13-tetraoxa-pentadecanoic-acid-tert-butyleste
15-Amino-4,7,10,13-tetraoxa-pentadecanoic-acid-tert-butylester
1-Amino-3,6,9,12-tetraoxapentadecan-15-oic Acid tert-Butyl Ester
2-[2-[2-[2-(2-tert-Butoxycarbonylethoxy)ethoxy]ethoxy]ethoxy]ethylamine
4,7,10,13-Tetraoxapentadecanoic acid, 15-amino-, 1,1-dimethylethyl ester
H2N-PEG4-CH2CH2COOtBu | [Molecular Formula]
C15H31NO6 | [MDL Number]
MFCD11041116 | [MOL File]
581065-95-4.mol | [Molecular Weight]
321.41 |
| Chemical Properties | Back Directory | [Boiling point ]
400.1±35.0 °C(Predicted) | [density ]
1.040±0.06 g/cm3(Predicted) | [refractive index ]
n/D 1.4508 | [storage temp. ]
-20°C | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [form ]
clear liquid | [pka]
8.74±0.10(Predicted) | [color ]
Colorless to Light yellow | [InChI]
InChI=1S/C15H31NO6/c1-15(2,3)22-14(17)4-6-18-8-10-20-12-13-21-11-9-19-7-5-16/h4-13,16H2,1-3H3 | [InChIKey]
PKESARRNSGIDRD-UHFFFAOYSA-N | [SMILES]
C(OC(C)(C)C)(=O)CCOCCOCCOCCOCCN | [CAS DataBase Reference]
581065-95-4 |
| Hazard Information | Back Directory | [Description]
Amino-PEG4-t-butyl ester is a PEG reagent containing an amino (NH2) and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl (Boc) can be deprotected under acidic conditions. | [Uses]
is a linker-cytotoxin conjugate. Linker-cytotoxin conjugate is related to antibody-cytotoxin and antibody-drug conjugates and related compounds. | [reaction suitability]
reagent type: cross-linking reagent | [Synthesis]
The general procedure for the synthesis of tert-butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate from 1-(p-toluenesulfonyloxy)-3,6,9,12-tetraoxapentadecan-15-oate is as follows: 150 g of the sulfonated crude product was dissolved in 200 mL of methylene chloride, followed by the addition of 100 g of ammonium hydroxide and 10 g of tetrabutyl ammonium bromide. The reaction mixture was warmed to 40 °C with continuous stirring for 24 hours. Upon completion of the reaction, the solvent was removed by rotary evaporation. To the residue, 3 M hydrochloric acid solution was added and the pH was adjusted to 3. The organic phase was separated by extracting twice with 300 mL of dichloromethane. The pH of the aqueous phase was then adjusted to 9 with sodium hydroxide solution and extracted three times with 400 mL of dichloromethane. The organic phases were combined, dried with anhydrous sodium sulfate, filtered and the solvent was removed by rotary evaporation to give 50 g of aminocapped product. The structure of the product was confirmed by NMR. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] Patent: WO2012/166560, 2012, A1
[2] Patent: WO2013/192360, 2013, A1
[3] Patent: WO2013/185117, 2013, A1
[4] Patent: CN107235848, 2017, A. Location in patent: Paragraph 0021 |
|
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
T&W GROUP
|
| Telephone: |
021-61551611 13296011611 |
| Website: |
www.trustwe.com/ |
|