| Identification | More | [Name]
Ethyl 1-Boc-3-piperidinecarboxylate | [CAS]
130250-54-3 | [Synonyms]
1-(TERT-BUTOXYCARBONYL)-3-(ETHOXYCARBONYL)PIPERIDINE
BOC-DL-NIPC-OET
BOC-DL-PIC(3)-EOT
BOC-DL-PIC(3)-OET
ETHYL 1-BOC-3-PIPERIDINECARBOXYLATE
ETHYL N-BOC-NIPECOTATE
N-T-BUTOXYCARBONYL-DL-3-PIPERIDINECARBOXYLIC ACID ETHYL ESTER
N-T-BUTOXYCARBONYL-DL-NIPECOTIC ACID ETHYL ESTER
N-T-BUTOXYCARBONYL-DL-PIPERIDINECARBOXYLIC ACID ETHYL ESTER
N-T-BUTOXYCARBONYL-(+/-)-NIPECOTIC ACID ESTER
N-T-BUTOXYCARBONYL-(+/-)-NIPECOTIC ACID ETHYL ESTER
N-T-BUTOXYCARBONYL-(R,S)-NIPECOTIC ACID ETHYL ESTER
N-T-BUTOXYCARBONYL-(R,S)-NIPOCITUC ACID ETHYL ESTER
N-T-BUTOXYCARBONYL-(R,S)-PIPERIDINE-3-CARBOXYLIC ACID ETHYL ESTER
PIPERIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-ETHYL ESTER
1-Boc-3-Piperidinecarboxylic acid ethyl ester
1-BOC-ETHYL NIPECOTATE
1,3-Piperidinedicarboxylic acid, 1-(1,1-dimethylethyl) 3-ethyl ester
1-(tert-butyl) 3-ethyl tetrahydro-1,3(2H)-pyridinedicarboxylate
1-(tert-Butyl) 3-ethyl 1,3-piperidinedicarboxylate | [EINECS(EC#)]
623-370-0 | [Molecular Formula]
C13H23NO4 | [MDL Number]
MFCD04116274 | [Molecular Weight]
257.33 | [MOL File]
130250-54-3.mol |
| Questions And Answer | Back Directory | [Synthesis]
Boc₂O (7.75 mL, 33.4 mmol) was added to a solution of ethyl piperidine-3-carboxylate (15 g, 95 mmol) in THF (159 mL) at room temperature, and the mixture was stirred for 16 h at room temperature. The resulting reaction mass was diluted with water (50 mL) and then extracted with ethyl acetate (3 x 100 mL). The combined organic extract was washed with saturated NaHCO₃ solution (1 x 200 mL) and brine (20 mL), dried (Na₂SO₄), filtered, and concentrated. The resulting residue was purified by ELSD ISCO on a 120 g silica gel column, eluting the compound in hexane to approximately 25% ethyl acetate. The pure fraction was collected and concentrated to give the desired product, 1-tert-butyl-3-ethylpiperidine-1,3-dicarboxylate. The final product, ethyl Ethyl 1-Boc-3-piperidinecarboxylate, was obtained in a yield of 23.39 g, 91 mmol, 95%. 
|
| Chemical Properties | Back Directory | [Melting point ]
31-35℃ | [Boiling point ]
95℃/0.5mm | [density ]
1.077±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [form ]
powder to lump | [pka]
-2.40±0.40(Predicted) | [color ]
White to Yellow to Orange | [Sensitive ]
Moisture & Light Sensitive | [BRN ]
3614917 | [InChI]
InChI=1S/C13H23NO4/c1-5-17-11(15)10-7-6-8-14(9-10)12(16)18-13(2,3)4/h10H,5-9H2,1-4H3 | [InChIKey]
YCXCRFGBFZTUSU-UHFFFAOYSA-N | [SMILES]
N1(C(OC(C)(C)C)=O)CCCC(C(OCC)=O)C1 | [CAS DataBase Reference]
130250-54-3(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Uses]
Reactant for synthesis of:
- GABAA receptor agonists
- Piperidine derivatives
- Selective TACE inhibitors
- HDL-elevating agents
- α-Sulfonyl hydroxamic acid derivatives
- chemicals in the Iboga-alkaloid family
| [Uses]
Reactant for synthesis of:• ;GABAA receptor agonists1• ;Piperidine derivatives2• ;Selective TACE inhibitors3• ;HDL-elevating agents4• ;α-Sulfonyl hydroxamic acid derivatives5• ;chemicals in the Iboga-alkaloid family6 |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
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| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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