| Identification | Back Directory | [Name]
GO 6983 | [CAS]
133053-19-7 | [Synonyms]
CS-674
gǒ 6983
GOE 6983
Gδ 6983
Go6983(96 %)
GO6983 GO-6983
GO 6983 USP/EP/BP
G 6983 - GO 6983 | Goe 6983
GOE 6983;GO6983 GO-6983;GO 6983
G 6983 - CAS 133053-19-7 - Calbiochem
3-[1-(3-Dimethylamino-propyl)-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-pyrrole-2,5-dione
1H-Pyrrole-2,5-dione, 3-[1-[3-(dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)- | [Molecular Formula]
C26H26N4O3 | [MDL Number]
MFCD04040031 | [MOL File]
133053-19-7.mol | [Molecular Weight]
442.51 |
| Chemical Properties | Back Directory | [Boiling point ]
709.0±60.0 °C(Predicted) | [density ]
1.31±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: 20 mg/mL, clear, red
| [form ]
powder | [pka]
8.02±0.60(Predicted) | [color ]
red
| [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| Hazard Information | Back Directory | [Description]
Go-6983 (133053-19-7) potent and pan-specific, ATP-competitive protein kinase C inhibitor. PKC isotype IC50s= 7, 7, 6, 10 and 60 nM for PKC α, β, γ, δ, ζ respectively.1 Suppresses stress induced HSP27 disassociation.2 Maintains rat embryonic stem cell pluripotency.3 Attenuates myocardial ischemia/reperfusion injury.4 | [Uses]
Go 6983, is a protein kinase C (PKC) inhibitor.Potent PKC Inhibitor | [Definition]
ChEBI: 3-[1-[3-(dimethylamino)propyl]-5-methoxy-3-indolyl]-4-(1H-indol-3-yl)pyrrole-2,5-dione is a member of indoles and a member of maleimides. | [Biological Activity]
Broad spectrum protein kinase C (PKC) inhibitor (IC 50 values are 7, 7, 6, 10, 60 and 20000 nM for PKC α , PKC β , PKC γ , PKC δ , PKC ζ and PKC μ respectively). Displays cardioprotective properties; reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury. | [Biochem/physiol Actions]
Protein kinase C (PKC) inhibitor that selectively inhibits several PKC isozymes (IC50 = 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ), but does not inhibit PKCμ (IC50 = 20 mM). | [storage]
-20°C | [References]
1) Gschwendt et al. (1996), Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase C isoenzymes; FEBS Lett., 392 77
2) Kato et al. (2001), Protein kinase inhibitors can suppress stress-induced dissociation of Hsp27; Cell Stress Chaperones, 6 16
3) Rajendran et al. (2013), Inhibition of protein kinase C signaling maintains rat embryonic stem cell pluripotency; J. Biol. Chem., 288 24351
4) Young et al. (2005), Go 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury; Cardiovasc, Drug Rev., 23 255 |
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