[Synthesis]
2-(4-iodophenyl)propan-2-ol (81 mg, 0.3 mmol), AgNO3 (1.6 mg, 3 mol%), Bi(OTf)3 (6 mg, 3 mol%) and K2S2O8 (245.8 mg, 3 eq) were added to a 2 ml reaction flask. Finally, 2 wt% DAPGS-750-M aqueous solution (0.6 ml, 0.5 M) was added, and the reaction flask was then capped and stirred. After stirring, the reaction mixture was extracted three times with ethyl acetate. The organic phases from the extractions were combined into a 50 mL round-bottom flask and evaporated using a Heidolph rotary evaporator at 120 rpm, 38 °C, and 0.1 MPa for approximately 5 min. Then, column chromatography was performed using 200-mesh silica gel with a petroleum ether:ethyl acetate ratio of approximately 20:1 as the developing solvent. The target compound, 4-iodoacetophenone, was obtained (52.4 mg, yield 71%, purity 98% as determined by HPLC, and its high purity was also reflected in the appearance, signal, and noise of the NMR spectrum). ¹H NMR (400 MHz, CDCl₃) δ 7.86–7.81 (m, 2H), 7.69–7.63 (m, 2H), 2.57 (s, 3H).
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