| Identification | More | [Name]
Sodium propionate | [CAS]
137-40-6 | [Synonyms]
MAGGRAN(R) NPR
MAGNESIA 87910
METHYLACETIC ACID SODIUM SALT
PROPANOIC ACID SODIUM SALT
PROPIONIC ACID SODIUM SALT
SODIUM PROPIONATE
bioban-s
component of Prophyllin
deketon
Impedex
keenate
Luprosil sodium salt
Mycoban
Napropion
Natriumpropionat
Ocuseptine
propianatedesodium
propiofar
propion
Propionan sodny | [EINECS(EC#)]
205-290-4 | [Molecular Formula]
C3H5NaO2 | [MDL Number]
MFCD00002759 | [Molecular Weight]
96.06 | [MOL File]
137-40-6.mol |
| Chemical Properties | Back Directory | [Appearance]
white powder | [Melting point ]
285-286 °C (lit.) | [density ]
1.51[at 20℃] | [vapor pressure ]
0Pa at 20℃ | [storage temp. ]
Store at RT. | [solubility ]
H2O: 0.1 g/mL, clear
| [form ]
Crystalline Powder | [color ]
White | [Odor]
at 100.00?%. bland | [PH]
8-9.5 (10g/l, H2O, 20℃) | [Stability:]
Stable. Incompatible with strong oxidizing agents. Hygroscopic. | [Water Solubility ]
995 g/L (20 ºC) | [Sensitive ]
Hygroscopic | [Merck ]
14,8669 | [BRN ]
3566934 | [LogP]
-3.23 at 25℃ | [Uses]
Sodium Propionate is an antimicrobial agent that is the sodium salt
of propionic acid. it occurs as colorless, transparent crystals or a gran-
ular crystalline powder. it is odorless or has a faint acetic–butyric acid
odor, and is deliquescent. it is prepared by neutralizing propionic acid
with sodium hydroxide. it is used in baked goods; nonalcoholic
beverages; cheeses; confections and frostings; gelatins, puddings, and
fillings; jams and jellies; meat products; and soft candy. | [CAS DataBase Reference]
137-40-6(CAS DataBase Reference) | [NIST Chemistry Reference]
Sodium propanoate(137-40-6) | [EPA Substance Registry System]
137-40-6(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R21:Harmful in contact with skin.
R38:Irritating to the skin.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S36/37:Wear suitable protective clothing and gloves .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
1
| [RTECS ]
UF7525000
| [F ]
3 | [TSCA ]
Yes | [HS Code ]
29159000 | [Safety Profile]
Moderately toxic by skin contact and subcutaneous routes. Mildly toxic by unspecified routes. An allergen. When heated to decomposition it emits toxic fumes of Na2O. | [Hazardous Substances Data]
137-40-6(Hazardous Substances Data) |
| Questions And Answer | Back Directory | [description]
Sodium propionate is the salt form of propionic acid, which is an organic acid that is produced during the chemical degradation of sugar. It is a compound that is produced naturally in the body when certain fatty acids and amino acids are metabolized. Propionic acid is metabolized by a series of enzymatic reactions that are dependent on the presence of vitamin B-12, according to a 1996 article in the "International Journal of Vitamin and Nutrition Research." Sodium propionate is also chemically manufactured for a variety of industrial uses.
Sodium propionate is a common food additive that is industrially manufactured but also occurs in nature. Since it is toxic to mold and some species of bacteria, it is an especially effective additive in baked goods or other products that are susceptible to spoilage.
sodium propionate is an effective inhibitor of the growth of certain molds and some bacteria in bakery goods. It is usually preferred in non-yeast leavened bakery products because the calcium ions’ of calcium propionate interfere with the chemical leavening agents. In those bakery products, such as cakes, tortillas, pie fillings etc., chemically leaved agents are used (e.g. baking powder). sodium propionate is easy to handle and easy to incorporate into flour.
It is a safe compound when encountered at the low levels found in food. | [Chemical properties]
It appears as transparent particles or crystal with specific smelly odor. It is easily subject to deliquescence in wet air. It is soluble in water, slightly soluble in alcohol. | [Uses]
Primary uses: Antifungal agent, antiseptic agent (topical), disinfectant, food additive, ophthalmic agent.
It is used primarily as a mold inhibitor in bakery products. It is approved for use as a food additive in the EU, USA and Australia and New Zealand (where it is listed by its INS number 281). Chemically synthesized sodium propionate is most commonly used as a preservative in the food industry. It prevents the growth of mold and some bacteria, thereby prolonging the shelf life of packaged baked goods. According to the Code of Federal Regulations, sodium propionate is generally recognized as safe when used as a food additive. It is also used to prevent mold growth in packaged and processed cheese products. In addition, ammonium propionate is used as an additive in animal feed to prevent overgrowth of unwanted bacteria in the stomachs of livestock.
- It can be used as preservatives; used for anti-mould for cakes, waxberry and other mildew
- It can be used as germicide and antiseptic.
- Sodium propionate wet acid preservative has its antibacterial effect be affected by the environmental PH. The minimum inhibitory concentration was 0.01% at pH 5.0 and 0.5% at pH 6.5. In acidic medium, it has a strong inhibitory effect against various types of mold, aerobic bacillus or Gram-negative bacteria. It has special effect in prevention the production of aflatoxin while having no effect on the yeast. In addition, it is also used as a food preservative.
- In the leather, it can be used as masking agent in order to improve the alkali resistance of leather and tanning uniformity.
- In the food industry, it can be used for pastry preservation with the usage amount of 2.5g/kg (based on propionic acid, the same as below); in 3% to 5% aqueous solution, the maximal amount for soaking waxberry is 50g/kg. It can also be used as feed antiseptic.
- Germicide, antiseptic. Used for determination of transaminase; The general dosage is 0.1-0.3%.
| [health risks]
Sodium propionate and calcium propionate are good preservatives, especially in food because very low toxicity has great advantages, bread usually calcium propionate, because bread is yeast fermentation, the use of sodium propionate can So that d increases dough, affecting yeast growth, will extend the time to face.
According to the Material Safety Data Sheet for sodium proprionate, as reported on ScienceLab.com, the pure chemical can irritate the skin if handled. However, since the general public would not come in contact with sodium propionate in its pure form, it does not likely present a risk. The risks of consuming sodium propionate are slight if you compare it to the possibility of consuming products that have mold or bacterial contamination. If you are worried about consuming sodium propionate, buy fresh bread or bake your own.
References: http://www.livestrong.com/article/501045-what-is-sodium-propionate/ | [Toxicity]
ADI has not been subject to any specific restriction (FAO/WHO, 2001).
LD50 5.1 g/kg (mouse, oral).
GRAS (FDA, § 184.1784, 2000). | [Usage limit]
GB 2760-96 (g/kg): pastry 2.5; soaking waxberry: 30 to 50; impregnated with 3% to 5% aqueous solution; should be washed before processing, calculated on propionic acid.
FAO/WHO (1984): processed cheese 3000mg/kg.
EEC regulations: it can be used for dairy products, bakery products, cheese and so on. Still used as beer and other viscous substances inhibitor. |
| Hazard Information | Back Directory | [Definition]
ChEBI: An organic sodium salt comprising equal numbers of sodium and propionate ions. | [Reactions]
It is produced by the reaction of propionic acid and sodium carbonate or sodium hydroxide. | [General Description]
This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ.
Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate.
Download your certificate at: http://www.sigma-aldrich.com. | [Flammability and Explosibility]
Notclassified | [Biological Activity]
If sodium propionate is ingested or applied topically in an acid media, it becomes propionic acid. It oxidizes fatty acids, lowers pH values, and facilitates the citric acid cycle through interaction with coenzyme A. There has been evidence of heightened production of insulin in cows and sheep; the insulin later settles to an overall lower level.
Propionic acid inhibits 14CO2 production from palmitate in both control and methylmalonic fibroblasts; propionic acid also inhibited ureagenesis in rat liver slices. These findings may explain the fatty degeneration of the liver and hyperammonemia in propionic and methylmalonic acidemia. Propionic acidemia is an autosomal recessive disorder caused by a defect of propionyl–coenzyme A carboxylase. The main clinical findings are vomiting, lethargy, hypotonia, and metabolic ketoacidosis, and early clinical onset occurs during the neonatal period in ～80% of the patients. | [Biochem/physiol Actions]
Sodium propionate has an ability to prevent ketosis in dairy cattle. | [Purification Methods]
Recrystallise it from H2O (solubility 10%) and dry by heating at 100o for 4hours. The solubility of the anhydrous salt in MeOH is 13% at 15o and 13.77% at 68o. It is insoluble in *C6H6 and Me2CO. [Henstock J Chem Soc 1341 1934, Beilstein 2 IV 701.] | [Mechanism of food preservation]
Sodium propionate at levels of 0.1–5.0% delays the growth of Staphylococcus aureus, Sarcina lutea, Proteus vulgaris, Lactobacillus plantarum, Torula and Saccharomyces ellipsoideus by 5 days. The bacteriostatic action of sodium propionate can be overcome by addition of small amounts of β-alanine for Escherichia coli, but not for other organisms such as Aspergillus clavatus, Bacillus subtilis, Pseudomonas spp. and Trichophyton mentagrophytes. It is believed that the inhibitory action of sodium propionate against E. coli may be due to interference with β-alanine synthesis.
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