| Identification | More | [Name]
Heptafluorobutyric anhydride | [CAS]
336-59-4 | [Synonyms]
AKOS B020344
BIS(HEPTAFLUORO-N-BUTYRIC) ANHYDRIDE
HEPTAFLUOROBUTYRIC ACID ANHYDRIDE
HEPTAFLUOROBUTYRIC ANHYDRIDE
HEPTAFLUORO-N-BUTYRIC ANHYDRIDE
HFAA
HFBA
PERFLUOROBUTYRIC ANHYDRIDE
PERFLUORO-N-BUTYRIC ANHYDRIDE
1,1,2,2,3,3,3-Heptafluorobutanoic anhydride
Butanoic acid, heptafluoro-, anhydride
Butanoicacid,heptafluoro-,anhydride
Heptafluorobutanoic anhydride
heptafluoro-butanoicacianhydride
HEPTAFLUOROBUTYRIC ANHYDRIDE SET WITH 10 X 1 ML
HEPTAFLUOROBUTYRIC ANHYDRIDE, DERIVATIZA TION GRADE
Heptafluorobutyric anhydride, 98+%
Heptafluorobutyric anhydride 98%
Heptafluorobutyric anhydride 99+%
heptafluoro-butanoic acid anhydride | [EINECS(EC#)]
206-410-8 | [Molecular Formula]
C8F14O3 | [MDL Number]
MFCD00000432 | [Molecular Weight]
410.06 | [MOL File]
336-59-4.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colorless liquid | [Melting point ]
−43 °C(lit.)
| [Boiling point ]
108-110 °C(lit.)
| [density ]
1.674 g/mL at 20 °C(lit.)
| [refractive index ]
n20/D 1.287(lit.)
| [Fp ]
None | [storage temp. ]
Room temp | [solubility ]
Miscible with halogenated solvents. Immiscible with polar solvents. | [form ]
Liquid | [color ]
Colorless to Almost colorless | [Specific Gravity]
1.653 | [Water Solubility ]
REACTS | [Sensitive ]
Hygroscopic | [Detection Methods]
GC,NMR,MS | [BRN ]
856036 | [Stability:]
Moisture Sensitive | [InChI]
1S/C8F14O3/c9-3(10,5(13,14)7(17,18)19)1(23)25-2(24)4(11,12)6(15,16)8(20,21)22 | [InChIKey]
UFFSXJKVKBQEHC-UHFFFAOYSA-N | [SMILES]
FC(F)(F)C(F)(F)C(F)(F)C(=O)OC(=O)C(F)(F)C(F)(F)C(F)(F)F | [CAS DataBase Reference]
336-59-4(CAS DataBase Reference) | [NIST Chemistry Reference]
Heptafluorobutyric anhydride(336-59-4) | [Storage Precautions]
Moisture sensitive | [EPA Substance Registry System]
336-59-4(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS05 | [Signal word ]
Danger | [Hazard statements ]
H314 | [Precautionary statements ]
P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405 | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 3265 8/PG 2
| [WGK Germany ]
3
| [F ]
10-21 | [Hazard Note ]
Corrosive/Hygroscopic | [TSCA ]
T | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29159080 | [Storage Class]
8A - Combustible corrosive hazardous materials | [Hazard Classifications]
Skin Corr. 1B |
| Hazard Information | Back Directory | [Chemical Properties]
clear colorless liquid | [Uses]
As a GC derivatizing agent, Heptafluorobutyric anhydride is used to prepare volatile derivatives of amino acids and other biologically active compounds.
| [Uses]
Heptafluorobutyric anhydride (HFAA) is frequently used as an acylating agent for the derivatization of primary and secondary amines (Walle and Ehrsson, 1971). Commercially available Heptafluorobutyric anhydride may afford low yields of the derivative due to the presence of Heptafluorobutyric acid (Moodie et al., 1985). This contaminant may be removed by ditillation over phosphorus pentoxide (Walle and Ehrsson, 1970).
HFAA is used to increase volatility of an analyte, and to introduce fluorine atoms for better detection limits in gas chromatography applications.
suzuki reaction | [Definition]
ChEBI: An acyclic carboxylic anhydride that is perfluorinated butyric anhydride. It is used as a derivatising reagent for gas chromatographic analyses. | [General Description]
Heptafluorobutyric anhydride is a perfluoroacylated acylation reagent, that forms stable, volatile derivatives with alcohols, amines, and phenols. It is majorly used to prepare electron-capturing derivatives for GC/electron capture detection. It is generally used with an acid scavenger, to help drive the reaction to completion and to prevent column damage from acidic by-products of the derivatization reaction. It is also used for the frequent testing of drugs of abuse such as, amphetamines and phencyclidine by GC-MS technique. | [reaction suitability]
reagent type: derivatization reagent
reaction type: Acylations |
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