| Identification | More | [Name]
Methyl 4-(chloroformyl)butyrate | [CAS]
1501-26-4 | [Synonyms]
5-CHLORO-5-OXOPENTANOIC ACID METHYL ESTER
CARBOMETHOXYL BUTYRYL CHLORIDE
GLUTARIC ACID MONOMETHYL ESTER CHLORIDE
METHYL 4-(CHLOROFORMYL)BUTYRATE
METHYL 5-CHLORO-5-OXOVALERATE
METHYL GLUTARYL CHLORIDE
5-chloro-5-oxo-pentanoicacimethylester
METHYL 5-CHLORO-5-OXOVALERATE,98%
Methyl glutarylchloride(Methyl 4-chloro-oxovalerate)
METHYL 5-CHLORO-5-OXOPENTANOATE
Methyl 4-(chloroformyl)butyrate, Methyl 5-chloro-5-oxovalerate, Methyl glutaryl chloride
Pentanoic acid, 5-chloro-5-oxo-, methyl ester
Methyl 4-(chloroformyl)-butyrate 98 %
5-Oxo-5-chloropentanoic acid methyl ester
5-Oxo-5-methoxypentanoic acid chloride | [EINECS(EC#)]
216-115-6 | [Molecular Formula]
C6H9ClO3 | [MDL Number]
MFCD00000756 | [Molecular Weight]
164.59 | [MOL File]
1501-26-4.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colourless to light yellow liquid | [Boiling point ]
110 °C/17 mmHg (lit.) | [density ]
1.191 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.445(lit.)
| [Fp ]
180 °F
| [storage temp. ]
2-8°C
| [solubility ]
Chloroform, Hexane | [form ]
Oil | [color ]
Clear Colourless | [Water Solubility ]
reacts | [Sensitive ]
Moisture Sensitive | [BRN ]
1762383 | [InChI]
1S/C6H9ClO3/c1-10-6(9)4-2-3-5(7)8/h2-4H2,1H3 | [InChIKey]
JCAZSWWHFJVFPP-UHFFFAOYSA-N | [SMILES]
COC(=O)CCCC(Cl)=O | [CAS DataBase Reference]
1501-26-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS05 | [Signal word ]
Danger | [Hazard statements ]
H314 | [Precautionary statements ]
P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405 | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S24/25:Avoid contact with skin and eyes . | [RIDADR ]
UN 3265 8/PG 2
| [WGK Germany ]
3
| [F ]
10-21 | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
2918300090 | [Storage Class]
8A - Combustible corrosive hazardous materials | [Hazard Classifications]
Skin Corr. 1B |
| Hazard Information | Back Directory | [Chemical Properties]
clear colourless to light yellow liquid | [Uses]
Methyl 4-(Chloroformyl)butyrate is used in the synthesis of Leukotriene B4, a proinflammatory agent produced from leukocytes. | [Synthesis]
1. 100 g (0.878 mol) of glutaric anhydride was dissolved in 50 mL of anhydrous methanol and heated to reflux for 1 h. 2. Upon completion of the reaction, unreacted methanol was removed by distillation under reduced pressure. 3. The reaction mixture was cooled to room temperature, and 200 mL of acetochloride was slowly added. 4. The reaction mixture was heated for 6 h., wherein after 2 h of heating the remaining dichloro sulfoxide.5. Finally, the fractions were dried at 96 °C to 98 °C/10 mmHg to give 124.2 g of methyl 4-chlorocarbonylbutyrate as a light yellow liquid in 86.4% yield. | [References]
[1] Patent: CN103864658, 2016, B. Location in patent: Paragraph 0056; 0057
[2] Tetrahedron Letters, 1984, vol. 25, # 39, p. 4371 - 4374
[3] Journal of Enzyme Inhibition and Medicinal Chemistry, 2016, vol. 31, # 6, p. 915 - 923 |
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| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|