| Identification | More | [Name]
2-PICOLINYL HYDRAZIDE | [CAS]
1452-63-7 | [Synonyms]
2-PICOLINYL HYDRAZIDE
AKOS B014996
AKOS BBS-00004147
ART-CHEM-BB B014996
PYRIDINE-2-CARBOHYDRAZIDE
PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE
Picolinylhydrazide
2-Pyridinecarboxylicacid,hydrazide(9CI)
2-pyridinecarboxylic acid hydrazide
2-PICOLINYL HYDRAZIDE 98+%
NSC-81875
Picolinic hydrazide
WS-104 | [Molecular Formula]
C6H7N3O | [MDL Number]
MFCD00059782 | [Molecular Weight]
137.14 | [MOL File]
1452-63-7.mol |
| Chemical Properties | Back Directory | [Melting point ]
100°C | [density ]
1.244 | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
11.29±0.10(Predicted) | [color ]
White to Off-White | [InChI]
1S/C6H7N3O/c7-9-6(10)5-3-1-2-4-8-5/h1-4H,7H2,(H,9,10) | [InChIKey]
BAQLNPIEFOYKNB-UHFFFAOYSA-N | [SMILES]
NNC(=O)c1ccccn1 | [CAS DataBase Reference]
1452-63-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
WGK 3 | [HazardClass ]
IRRITANT | [HS Code ]
29333990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Irrit. 2 |
| Hazard Information | Back Directory | [Chemical Properties]
White to off-white solid | [Uses]
Pyridine-2-carboxylic acid hydrazide is an impurity of Isoniazid (I821450), which is an antibiotic for treatment of Mycobacterium tuberculosis and inhibits mycolic acid biosynthesis. Intermediate used for the synthesis of analogs of antitumor agent 1-acetyl-2-picolinoylhydrazine.
| [Synthesis]
General procedure for the synthesis of 2-pyridinecarbohydrazide from ethyl 2-pyridinecarboxylate: a mixed solution of ethyl pyridine-2-carboxylate (90 g) and hydrazine hydrate (60 g) in ethanol (400 ml) was reacted with stirring at 80°C for 4 hours. After completion of the reaction, the solvent was removed by evaporation to give the crude product. The crude product was co-stirred with ether and the resulting suspension was filtered and the wet filter cake was washed with a small amount of ethanol (50 mL) to give 76 g (93% yield) of 2-pyridinecarbohydrazide as a white solid. Mass spectral data: m/z 138.0 (M+H). | [References]
[1] Patent: WO2010/136971, 2010, A1. Location in patent: Page/Page column 12
[2] Patent: US2012/142710, 2012, A1. Location in patent: Page/Page column 6
[3] Patent: WO2012/76989, 2012, A1. Location in patent: Page/Page column 55; 64
[4] Asian Journal of Chemistry, 2010, vol. 22, # 7, p. 5535 - 5542
[5] Patent: WO2017/106427, 2017, A1. Location in patent: Page/Page column 37-38 |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Shangchem Co., Ltd.
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| Telephone: |
+86-21-68182121 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList14031/0_EN.htm |
| Company Name: |
Maya High Purity Chemicals
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| Telephone: |
+86 (573) 82222445 (0)18006601000 452520369 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15221/0_EN.htm |
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