| Identification | More | [Name]
Ethyl 2-amino-4-methylthiazole-5-carboxylate | [CAS]
7210-76-6 | [Synonyms]
2-AMINO-4-METHYL-5-THIAZOLECARBOXYLIC ACID ETHYL ESTER
2-AMINO-4-METHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
AKOS B000345
AKOS BB-9152
ASISCHEM Y51232
BUTTPARK 34\01-17
ETHYL 2-AMINO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE
ETHYL 2-AMINO-4-METHYLTHIAZOLE-5-CARBOXYLATE
IFLAB-BB F1920-0015
OTAVA-BB BB0108540072
TIMTEC-BB SBB000257
ethyl-2-amino-4-methyl-5-thiazolecarboxylate
ETHYL 2-AMINO-4-METHYLTHIAZOLE-5-CARBOX&
Ethyl 2-amino-4-methylthiazole-5-carboxylate 98%
2-Amino-4-methyl-5-ethoxycarbonyl-thiazole | [EINECS(EC#)]
628-116-2 | [Molecular Formula]
C7H10N2O2S | [MDL Number]
MFCD00123414 | [Molecular Weight]
186.23 | [MOL File]
7210-76-6.mol |
| Chemical Properties | Back Directory | [Appearance]
off-white powder | [Melting point ]
176-180 °C(lit.)
| [Boiling point ]
313.1±22.0 °C(Predicted) | [density ]
1.283±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS pH 7.2 (1:1): 0.5 mg/ml | [form ]
powder to crystal | [pka]
3.90±0.10(Predicted) | [color ]
White to Almost white | [Water Solubility ]
insoluble | [InChI]
InChI=1S/C7H10N2O2S/c1-3-11-6(10)5-4(2)9-7(8)12-5/h3H2,1-2H3,(H2,8,9) | [InChIKey]
WZHUPCREDVWLKC-UHFFFAOYSA-N | [SMILES]
S1C(C(OCC)=O)=C(C)N=C1N | [CAS DataBase Reference]
7210-76-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R22:Harmful if swallowed. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S22:Do not breathe dust . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29349990 |
| Hazard Information | Back Directory | [Chemical Properties]
off-white powder | [Uses]
Ethyl 2-amino-4-methylthiazole-5-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | [Synthesis]
Thiourea (2.55 g, 0.033 mol, 1.1 eq.) was added to a solution of ethyl 2-chloro-3-oxobutanoate (5 g, 0.030 mol, 1 eq.) in ethanol (25 mL) at 25 °C. The reaction mixture was heated to reflux and kept for 3 hours. Upon completion of the reaction, the reaction mixture was slowly cooled to 25 °C under continuous stirring to induce precipitation of the product as a white solid. The precipitated solid was collected by filtration through a Büchner funnel and dried under vacuum to afford ethyl 2-amino-4-methylthiazole-5-carboxylate (4.8 g, 64% yield) as a final fine white powder. | [References]
[1] Patent: CN108570017, 2018, A. Location in patent: Paragraph 0030; 0031; 0033; 0035; 0037
[2] Chemical Biology and Drug Design, 2016, vol. 87, # 4, p. 508 - 516
[3] Patent: CN102942565, 2016, B. Location in patent: Paragraph 0028-0031; 0087-0088
[4] Archiv der Pharmazie, 2017, vol. 350, # 2,
[5] Acta Poloniae Pharmaceutica - Drug Research, 2017, vol. 74, # 6, p. 1699 - 1709 |
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