| Identification | More | [Name]
Pilocarpine nitrate | [CAS]
148-72-1 | [Synonyms]
3-ETHYLDIHYDRO-4-[(1-METHYL-1H-IMIDAZOL-5-YL)-METHYL]-2-(3H)-FURANONE NITRATE
PILOCARPINE NITRATE
PILOCARPINE NITRATE SALT
3-ethyldihydro-4-[(1-methyl-1h-imidazol-5-yl)methyl]-2(3h)-furanon(3s-cis)
p.v.carpineliquifilm
pilocarpine,mononitrate
Pilocarpinenitrateusp
pilocarpinesubnitrate
pilofrin
PILOCARPINE NITRATE, PH EUR
2(3H)-Furanone, 3-ethyldihydro-4-(1-methyl-1H-imidazol-5-yl)methyl-, (3S,4R)-, mononitrate
PILOCARPINENITRATE,CRYSTAL,USP
Pilagan
Pilocarpinnitrat
(3S)-3-Ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one nitrate
(3S,4R)-3-Ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone mononitrate
Pilocarpini nitras | [EINECS(EC#)]
205-723-7 | [Molecular Formula]
C11H17N3O5 | [MDL Number]
MFCD00078497 | [Molecular Weight]
271.27 | [MOL File]
148-72-1.mol |
| Chemical Properties | Back Directory | [Appearance]
White or almost white, crystalline powder or colourless crystals, sensitive to light. | [Melting point ]
173,5-174°C | [alpha ]
D +77 to +83° (c = 10) | [refractive index ]
81 ° (C=2, H2O) | [storage temp. ]
2-8°C
| [solubility ]
H2O: 0.1 g/mL, clear, very faintly yellow
| [form ]
powder | [color ]
white | [Optical Rotation]
[α]25/D +83°, c = 10 in H2O(lit.) | [Water Solubility ]
H2O: 100mg/mL | [Merck ]
7424 | [BRN ]
4171406 | [Major Application]
pharmaceutical (small molecule) | [InChI]
1S/C11H16N2O2.HNO3/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;2-1(3)4/h5,7-8,10H,3-4,6H2,1-2H3;(H,2,3,4)/t8-,10-;/m0./s1 | [InChIKey]
PRZXEPJJHQYOGF-GNAZCLTHSA-N | [SMILES]
O[N+]([O-])=O.CC[C@H]1[C@H](COC1=O)Cc2cncn2C | [CAS DataBase Reference]
148-72-1(CAS DataBase Reference) | [EPA Substance Registry System]
148-72-1(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,T+ | [Risk Statements ]
R22:Harmful if swallowed.
R26/28:Very Toxic by inhalation and if swallowed . | [Safety Statements ]
S1:Keep locked up .
S25:Avoid contact with eyes .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
3087 | [WGK Germany ]
3
| [RTECS ]
TK1455000
| [F ]
3-10 | [TSCA ]
TSCA listed | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
2939800000 | [Storage Class]
5.1B - Oxidizing hazardous materials | [Hazard Classifications]
Acute Tox. 2 Inhalation
Acute Tox. 4 Oral
Ox. Sol. 2 | [Toxicity]
LD50 oral in rat: 911mg/kg |
| Hazard Information | Back Directory | [Chemical Properties]
White or almost white, crystalline powder or colourless crystals, sensitive to light. | [Uses]
Pilocarpine nitrate salt has been used to measure bronchoconstriction and M2 and M3 muscarinic receptor function in vivo. It has also been used to induce electrographic and behavioral seizures and to study the different patterns of neuronal activation and neurodegeneration in Proechimys rats and Wistar rats. | [Uses]
antiglaucoma agent, miotic | [Uses]
Antiglaucoma drug;Cholinergic | [Brand name]
Pilagan (Allergan). | [General Description]
Pilocarpine mononitrate occursas shining white crystals that are not hygroscopic butare light sensitive. It is soluble in water (1:4) and alcohol(1:75) but insoluble in chloroform and ether. Aqueoussolutions are slightly acid to litmus and may be sterilizedin the autoclave. The alkaloid is incompatible with alkalies,iodides, silver nitrate, and reagents that precipitatealkaloids. | [Biochem/physiol Actions]
Pilocarpine is a cholinergic muscarinic agonist, useful in inducing epilepsy in animal models. It is specially used to study the pathogenesis of epileptogenesis and pharmacoresistant epilepsy. Pilocarpine application is more popular among the rat and mice models. |
|
| Company Name: |
Spectrum Chemical Manufacturing Corp.
|
| Telephone: |
021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Rhawn Reagent
|
| Telephone: |
400-400-1332688 18019345275 |
| Website: |
http://www.rhawn.cn |
|