ChemicalBook--->CAS DataBase List--->149577-05-9

149577-05-9

149577-05-9 Structure

149577-05-9 Structure
IdentificationBack Directory
[Name]

m-PEG2-acid
[CAS]

149577-05-9
[Synonyms]

mPEG2-COOH
mPEG1-COOH
m-PEG2-acid
m-dPEG2-acid
m-dPEG??-acid
MeOCH2CH2OCH2COOH
3-(2-Methoxyethoxy)propionic Acid
Propanoic acid, 3-(2-methoxyethoxy)-
[Molecular Formula]

C6H12O4
[MDL Number]

MFCD09939037
[MOL File]

149577-05-9.mol
[Molecular Weight]

148.16
Chemical PropertiesBack Directory
[Boiling point ]

244.2±20.0 °C(Predicted)
[density ]

1.098±0.06 g/cm3(Predicted)
[storage temp. ]

Sealed in dry,Room Temperature
[form ]

Liquid
[pka]

4.28±0.10(Predicted)
[color ]

Colorless to light yellow
[InChI]

InChI=1S/C6H12O4/c1-9-4-5-10-3-2-6(7)8/h2-5H2,1H3,(H,7,8)
[InChIKey]

KWMXBFIAGYXCCC-UHFFFAOYSA-N
[SMILES]

C(O)(=O)CCOCCOC
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)Corrosion (GHS05)
GHS07,GHS05
[Signal word ]

Danger
[Hazard statements ]

H318-H335-H315
[Precautionary statements ]

P280-P305+P351+P338-P310-P264-P280-P302+P352-P321-P332+P313-P362
Hazard InformationBack Directory
[Description]

m-PEG2-acid is a PEG linker containing a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media.
[Uses]

m-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
[Definition]

ChEBI:3-(2-methoxyethoxy)propanoic acid is a monocarboxylic acid that is propanoic acid substituted at C-3 by a 2-methoxyethoxy group. It has a role as a metabolite. It is a monocarboxylic acid and an ether.
[IC 50]

PEGs
[References]

[1] Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67. DOI:10.3762/bjoc.11.74
Spectrum DetailBack Directory
[Spectrum Detail]

m-PEG2-acid(149577-05-9)1HNMR
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