| Identification | Back Directory | [Name]
ETOXAZOLE | [CAS]
153233-91-1 | [Synonyms]
yi-5301
etoxazol
ETOXAZOLE
Etoxazole-D5
ETOXAZOLE STANDARD
etoxazole (bsi, pa iso)
2-(2,6-Difluorophenyl)-4-...
Etoxazole@100 μg/mL in Methanol
Etoxazole@1000 μg/mL in Acetone
4-(4-(tert-Butyl)-2-ethoxyphenyl)-2-(2,6-difluorophenyl)-4,5-dihydrooxazole
2-(2,6-Difluorophenyl)-4-[4-(tert-butyl)-2-ethoxyphenyl]-4,5-dihydrooxazole
4-(4-tert-butyl-2-ethoxyphenyl)-2-(2,6-difluorophenyl)-4,5-dihydro-1,3-oxazole
Oxazole, 2-(2,6-difluorophenyl)-4-4-(1,1-dimethylethyl)-2-ethoxyphenyl-4,5-dihydro-
2-(2,6-Difluorophenyl)-4-(4-(1,1-dimethylethyl)-2-ethoxyphenyl)-4,5-di hydrooxazole | [EINECS(EC#)]
201-167-4 | [Molecular Formula]
C21H23F2NO2 | [MDL Number]
MFCD07363987 | [MOL File]
153233-91-1.mol | [Molecular Weight]
359.41 |
| Chemical Properties | Back Directory | [Appearance]
Pale-yellow liquid when pure or reddish-brown
liquid or semisolid as a technical product. Mild odor.
| [Melting point ]
101-102° | [Boiling point ]
449.1±45.0 °C(Predicted) | [density ]
1.15±0.1 g/cm3(Predicted) | [Fp ]
457℃ | [storage temp. ]
0-6°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
neat | [pka]
2.04±0.70(Predicted) | [color ]
White to Off-White | [BRN ]
8930214 | [Henry's Law Constant]
9.6×101 mol/(m3Pa) at 25℃, Duchowicz et al. (2020) | [Stability:]
Hygroscopic | [Major Application]
agriculture
environmental | [InChI]
InChI=1S/C21H23F2NO2/c1-5-25-18-11-13(21(2,3)4)9-10-14(18)17-12-26-20(24-17)19-15(22)7-6-8-16(19)23/h6-11,17H,5,12H2,1-4H3 | [InChIKey]
IXSZQYVWNJNRAL-UHFFFAOYSA-N | [SMILES]
O1CC(C2=CC=C(C(C)(C)C)C=C2OCC)N=C1C1=C(F)C=CC=C1F | [EPA Substance Registry System]
Etoxazole (153233-91-1) |
| Hazard Information | Back Directory | [Chemical Properties]
Pale-yellow liquid when pure or reddish-brown
liquid or semisolid as a technical product. Mild odor.
| [Uses]
Etoxazole is a acaricide/insecticide that works via chitin biosynthesis inhibition for the control of mites. | [Uses]
Acaricide. | [Potential Exposure]
Aromatic hydrocarbon; Thiazole fungicide Etridiazole is a fungicide used in some countries as
a seed treatment on barley, beans, corn, cotton, peanuts,
peas, sorghum, soybeans, safflower, and wheat. It is
also used on cotton for in-furrow application at planting, on
ornamental plants and shrubs by horticultural nurseries, on
nonbearing citrus and nonbearing coffee, and for golf
course fairways, tees and greens. Some states hold Special
Local Need registrations for use on tobacco transplants | [First aid]
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts the
skin, remove contaminated clothing and wash immediately
with soap and water. Seek medical attention immediately.
If this chemical has been inhaled, remove from exposure,
begin rescue breathing (using universal precautions) if
breathing has stopped, and CPR if heart action has stopped.
Transfer promptly to a medical facility. When this chemical
has been swallowed, get medical attention. Give large
quantities of water and induce vomiting. Do not make an
unconscious person vomit. Do not induce vomiting when
formulations containing petroleum solvents are ingested | [Shipping]
UN2810 Toxic liquids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required. Military driver shall be given full and
complete information regarding shipment and conditions in
case of emergency. AR 50-6 deals specifically with the
shipment of chemical agents. Shipments of agent will be
escorted in accordance with AR 740-32. | [Incompatibilities]
Diazo compounds can detonate. This
applies in particular to organic azides that have been sensitized by the addition of metal salts or strong acids. Toxic
gases are formed by mixing materials of this class with
acids, aldehydes, amides, carbamates, cyanides, inorganic
fluorides, halogenated organics, isocyanates, ketones,
metals, nitrides, peroxides, phenols, epoxides, acyl halides,
and strong oxidizing or reducing agents. Flammable gases
are formed by mixing materials in this group with alkali
metals. Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides. This
chemical is sensitive to prolonged exposure to heat. This
chemical is incompatible with strong oxidizing agents | [Description]
Etoxazole is an organofluorine acaricide.1,2 It induces toxicity in two-spotted spider mite (T. urticae) larvae (LC50 = 0.036 mg/L for the London reference strain) through inhibition of chitin synthase 1. It reduces acetylcholinesterase (AChE) activity in the freshwater fish O. niloticus in a concentration-dependent manner.3 Etoxazole (2.2-22 mg/kg per day) inhibits the activity of catalase, glutathione peroxidase (GPX), and AChE in the liver and kidneys of rats in a dose-dependent manner.2 Formulations containing etoxazole have been used for the control of mites in agriculture. | [Waste Disposal]
Incineration would be an
effective disposal procedure where permitted. If an efficient
incinerator is not available, the product should be mixed
with large amounts of combustible material and contact
with the smoke should be avoided. In accordance with
40CFR165, follow recommendations for the disposal of
pesticides and pesticide containers | [Definition]
ChEBI: Etoxazole is an organofluorine acaricide. | [Production Methods]
The commercial production of etoxazole involves synthesising a diphenyl oxazoline derivative, a structure that underpins its potent acaricidal activity. The process begins with constructing the oxazoline ring and attaching two phenyl groups, one of which carries a key substituent that enhances selectivity against mite eggs and larvae. | [Mechanism of action]
Non-systemic with contact action. A moulting hormone agonist. Mite growth inhibitor affecting CHS1. | [storage]
Store at -20°C | [References]
[1] PETER DEMAEGHT . High resolution genetic mapping uncovers chitin synthase-1 as the target-site of the structurally diverse mite growth inhibitors clofentezine, hexythiazox and etoxazole in Tetranychus urticae[J]. Insect Biochemistry and Molecular Biology, 2014, 51: Pages 52-61. DOI: 10.1016/j.ibmb.2014.05.004
[2] MEHMET YILMAZ Mustafa C Eyyup Rencuzogullari. Investigations on the effects of etoxazole in the liver and kidney of Wistar rats[J]. Environmental Science and Pollution Research, 2017, 24 24: 19635-19639. DOI: 10.1007/s11356-017-9601-5
[3] YUSUF SEVGILER Nevin ü Elif ?zcan Oru?. Evaluation of etoxazole toxicity in the liver of Oreochromis niloticus[J]. Pesticide Biochemistry and Physiology, 2004, 78 1: Pages 1-8. DOI: 10.1016/j.pestbp.2003.09.004 | [Pesticide Type]
Acaricide |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS09 | [Signal word ]
Warning | [Hazard statements ]
H410 | [Precautionary statements ]
P273 | [Hazard Codes ]
N | [Risk Statements ]
50/53 | [Safety Statements ]
60-61 | [RIDADR ]
UN 3077 9 / PGIII | [WGK Germany ]
3 | [RTECS ]
RP6795100 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Aquatic Acute 1
Aquatic Chronic 1 | [Hazardous Substances Data]
153233-91-1(Hazardous Substances Data) | [Toxicity]
LD50 in rats (mg/kg): >5000 orally; >2000 dermally; LC50 (96 hr) in Japanese carp: 0.89 mg/l (Ishida) |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
SPIRO PHARMA
|
| Telephone: |
|
| Website: |
www.spiropharma.com.cn |
|