| Identification | Back Directory | [Name]
2-Methyl-5-nitrobenzaldehyde | [CAS]
16634-91-6 | [Synonyms]
2-METHYL-5-NITROBENZALDEHYDE
Benzaldehyde, 2-methyl-5-nitro-
2-METHYL-5-NITROBENZALDEHYDE, 95+% | [Molecular Formula]
C8H7NO3 | [MDL Number]
MFCD03840506 | [MOL File]
16634-91-6.mol | [Molecular Weight]
165.15 |
| Chemical Properties | Back Directory | [Melting point ]
53.0 to 57.0 °C | [Boiling point ]
114°C/0.2mmHg(lit.) | [density ]
1.278±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [form ]
powder to crystal | [color ]
White to Light yellow to Light orange |
| Hazard Information | Back Directory | [Synthesis]
General steps:
1. In a dry reaction flask, 2-methyl-5-nitrobenzyl alcohol (20 mmol) was dissolved in dichloromethane (DCM, 100 mL).
2. Pyridinium chlorochromate (PCC, 28-40 mmol) was added to the above solution.
3. The reaction mixture was heated to reflux (oil bath temperature was maintained at 55 °C) and the reaction lasted for 1-4 hours.
4. The progress of the reaction was monitored by thin layer chromatography (TLC) and/or liquid chromatography-mass spectrometry (LCMS) during the reaction.
5. Upon completion of the reaction, the mixture was cooled to room temperature.
6. post-processing, including isolation and purification of the product, is carried out according to the method described in variant B. | [References]
[1] Patent: US2015/218086, 2015, A1. Location in patent: Paragraph 0529; 0530; 0573
[2] Patent: WO2017/24009, 2017, A1. Location in patent: Paragraph 0560; 0592 |
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