| Identification | More | [Name]
(R)-3-Amino-3-phenylpropan-1-ol | [CAS]
170564-98-4 | [Synonyms]
(R)-1-PHENYL-3-PROPANOLAMINE
(R)-3-AMINO-3-PHENYLPROPAN-1-OL
(R)-BETA-PHENYLALANINOL
(R)-3-Amino-3-phenylpropan-1-ol(e.e.)
(R)-3-Amino-3-phenylpropan-1-ol, 98% ee, 95%
(R)-3-PHENYL-BETA-ALANINOL
(3R)-3-amino-3-phenylpropan-1-ol
(R)-3-AMINO-3-PHENYLPROPAN-1-OL 95% (98% E.E.)
(R)-3-Amino-3-phenylpropan-1-ol, 95%, ee:98% | [Molecular Formula]
C9H13NO | [MDL Number]
MFCD01311791 | [Molecular Weight]
151.21 | [MOL File]
170564-98-4.mol |
| Chemical Properties | Back Directory | [Appearance]
pale yellow viscous liquid or almost white | [Melting point ]
77°C(lit.) | [Boiling point ]
273.23°C (rough estimate) | [density ]
1.0406 (rough estimate) | [refractive index ]
1.4755 (estimate) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [solubility ]
Dichloromethane (Sparingly), DMSO (Slightly), Methanol (Slightly, Heated) | [form ]
Viscous Liquid or Low Melting Solid | [pka]
14.90±0.10(Predicted) | [color ]
Pale yellow or almost white to slightly yellow | [Optical Rotation]
Consistent with structure | [Detection Methods]
GC,NMR | [CAS DataBase Reference]
170564-98-4(CAS DataBase Reference) | [Storage Precautions]
Air sensitive;Store under nitrogen |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
UN 3259 8/PG III | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29211990 |
| Hazard Information | Back Directory | [Chemical Properties]
pale yellow viscous liquid or almost white | [Synthesis]
(R)-4-Amino-4-phenyl-1-butene (0.04 mol) was dissolved in 200 ml of methanol in a simple ozonolysis apparatus without gas recycling and was cooled to - 20℃. The ozone generator was fed continuously with air. A concentration of 20 g/m3 (ST. P.) of ozone was produced and was completely reactive in the ozonolysis apparatus. After the end of the ozonolysis, the reaction solution was added dropwise over the course of 10 min to 100 ml of an ice-cooled methanolic sodium borohydride solution (0.9 mol/l). The reaction solution was then warmed to room temperature, and 10 ml of water was added to decompose excess sodium borohydride. After the solvent had been distilled off, the residue was extracted several times with dichloromethane, and the combined organic phases were dried over sodium sulfate and filtered. After the solvent had been distilled off, 0.37 mol of (R)-1-Phenyl-3-propanolamine (melting point 73-74°C) was obtained in 99% enantiomeric excess (93% yield).
| [References]
[1] Patent: WO2005/63682, 2005, A1. Location in patent: Page/Page column 11
[2] Patent: US2007/123589, 2007, A1
[3] Patent: WO2008/77769, 2008, A1. Location in patent: Page/Page column 22 |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|