| Identification | More | [Name]
Ethyl 1-Boc-3-pyrrolidinecarboxylate | [CAS]
170844-49-2 | [Synonyms]
ETHYL 1-BOC-3-PYRROLIDINECARBOXYLATE
PYRROLIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-ETHYL ESTER
ETHYL 1-BOC-BETA-PROLINATE
N-Boc-3-ethyl pyrrolidine-
carboxylate
N-Boc-3-Pyrrolidinecaboxylic acid ethyl ester | [Molecular Formula]
C12H21NO4 | [MDL Number]
MFCD03791256 | [Molecular Weight]
243.3 | [MOL File]
170844-49-2.mol |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302 | [Precautionary statements ]
P301+P312+P330 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
3 | [HazardClass ]
IRRITANT | [HS Code ]
2933998090 |
| Hazard Information | Back Directory | [Synthesis]
A dichloromethane (50 mL) solution of di-tert-butyl dicarbonate (10.30 g, 47.2 mmol) was slowly added dropwise to a dichloromethane (50 mL) solution of crude ethyl 3-pyrrolidinecarboxylate (7.12 g) at 0 °C for a controlled time of 10 min or more. The reaction mixture was gradually warmed up to room temperature over 18 h. The mixture was washed with water and saturated saline, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford ethyl N-Boc-3-pyrrolidinecarboxylate (10.4 g, 100% yield), which could be used for the subsequent reaction without further purification.1H NMR (CDCl3) δ: 4.14 (q, 2H), 3.27-3.69 (m , 4H), 3.02 (m, 1H), 2.07-2.16 (m, 2H), 1.46 (s, 9H), 1.27 (t, 3H). | [References]
[1] Patent: WO2005/49602, 2005, A1. Location in patent: Page/Page column 89; 90; 130
[2] Patent: WO2005/49605, 2005, A1. Location in patent: Page/Page column 117; 118; 158 |
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