| Identification | Back Directory | [Name]
PROTHIOCONAZOLE | [CAS]
178928-70-6 | [Synonyms]
jau 6476
Thiazole propionate
Prothioconazole Solution
Prothioconazole PESTANAL
prothioconazole (bsi, pa iso)
Prothioconazole@100 μg/mL in Acetonitrile
Prothioconazole@1000 μg/mL in Acetonitrile
2-(2-(1-Chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl)-1H-1,2,4-triazole-3(2H)-thione
3H-1,2,4-Triazole-3-thione, 2-2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl-1,2-dihydro-
2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-1,2-dihydro-3H-1,2,4-triazole-3-thione
2-[2-(1-Chloro-cyclopropyl)-3-(2-chlorophenyl)-2-hydroxy-propyl]-1,2-dihydro-3H-1,2,4-Triazol-3-thione
2-[2-(1-Chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-1,2-dihydro-3H-1,2,4-triazole-3-thione 95+% | [EINECS(EC#)]
605-841-2 | [Molecular Formula]
C14H15Cl2N3OS | [MDL Number]
MFCD08273847 | [MOL File]
178928-70-6.mol | [Molecular Weight]
344.259 |
| Chemical Properties | Back Directory | [Melting point ]
139.1-144.5° | [Boiling point ]
486.7±55.0 °C(Predicted) | [density ]
1.50±0.1 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
neat | [pka]
6.9(at 25℃) | [color ]
White to light yellow | [InChI]
InChI=1S/C14H15Cl2N3OS/c15-11-4-2-1-3-10(11)7-14(20,13(16)5-6-13)8-19-12(21)17-9-18-19/h1-4,9,20H,5-8H2,(H,17,18,21) | [InChIKey]
MNHVNIJQQRJYDH-UHFFFAOYSA-N | [SMILES]
N1C=NC(=S)N1CC(C1(Cl)CC1)(O)CC1=CC=CC=C1Cl | [LogP]
1.770 (est) | [EPA Substance Registry System]
3H-1,2,4-Triazole-3-thione, 2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-1,2-dihydro- (178928-70-6) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,N | [Risk Statements ]
51/53 | [Safety Statements ]
61 | [RIDADR ]
UN3077 9/PG 3 | [WGK Germany ]
2 | [HS Code ]
2933998090 | [Hazardous Substances Data]
178928-70-6(Hazardous Substances Data) | [Toxicity]
LD50 in rats (mg/kg): > 6200 orally; > 2000 dermally; LC50 in rats (mg/m3): > 4990 by inhalation; LC50 (96 hr) in rainbow trout: 1.83 mg/l (Mauler-Machnik) |
| Hazard Information | Back Directory | [Uses]
Agricultural fungicide. | [Definition]
ChEBI: 2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-1,2-dihydro-1,2,4-triazole-3-thione is a member of the class of triazoles that is 1,2,4-triazole-3-thione substituted at position 2 by a 2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl group. It is a member of monochlorobenzenes, a member of triazoles, a tertiary alcohol, a member of cyclopropanes and a thiocarbonyl compound. | [Synthesis]
The general procedure for the synthesis of 2-(2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl)-1,2,4-triazolidine-3-thione from 2-(2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl)-1H-1,2,4-triazolidine-3(2H)-thione was carried out as follows: 2-(1-chlorocyclopropan-1-yl)-1-(2- chlorophenyl)-2-hydroxy-3-(1,2,4-triazolidine-5-thioxo-1-)propane IV (34.6 g, 0.10 mol) was dissolved in acetone (50 mL), followed by slow dropwise addition of hydrogen peroxide (0.15 mmol). The reaction mixture was stirred at 25°C for 2 hours. Upon completion of the reaction, sodium sulfite (6.5 g) was added to the reaction solution and stirring was continued for 1 h at room temperature and the end point of the reaction was detected using potassium iodide starch test paper. Water (50 mL) was added to the reaction system, followed by extraction with ethyl acetate (50 mL each time, three times). The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product (35 g, 90% purity). The crude product was recrystallized from toluene to give prothioconazole (31.6 g) as a white solid in 98% yield and 90% purity. | [References]
[1] Patent: CN106986838, 2017, A. Location in patent: Paragraph 0055; 0056; 0057; 0058; 0061 |
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