1807512-37-3

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1807512-37-3 Structure

Identification	Back Directory
[Name] THP-SS-PEG1-Tos
[CAS] 1807512-37-3
[Synonyms] THP-SS-PEG1-Tos Ethanol, 2-[[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]dithio]-, 1-(4-methylbenzenesulfonate)
[Molecular Formula] C16H24O5S3
[MDL Number] MFCD28950768
[MOL File] 1807512-37-3.mol
[Molecular Weight] 392.55

Hazard Information	Back Directory
[Description] THP-SS-PEG1-Tos is a cleavable linker containing a THP protecting group and a tosyl end group. Tos is a good leaving group by reacting with nucleophiles, The disulfide bonds can be cleaved by using Dithiothreitol (DTT) reagent.
[Uses] THP-SS-PEG1-Tos is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
[IC 50] Disulfide Cleavable Linker; Cleavable Linker
[References] [1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268

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