| Identification | Back Directory | [Name]
THP-PEG8-Tos | [CAS]
669556-37-0 | [Synonyms]
THP-PEG8-Tos
Tos-PEG6-THP
3,6,9,12,15-Pentaoxaheptadecan-1-ol, 17-[(tetrahydro-2H-pyran-2-yl)oxy]-, 1-(4-methylbenzenesulfonate) | [Molecular Formula]
C24H40O10S | [MDL Number]
MFCD31692200 | [MOL File]
669556-37-0.mol | [Molecular Weight]
520.63 |
| Hazard Information | Back Directory | [Description]
THP-PEG7-Tos is a PEG linker with a THP protecting group and a tosyl moiety. The THP is an alcohol protecting group that can be removed under acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media. | [Uses]
THP-PEG8-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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| Company Name: |
Xinyanpomei
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| Tel: |
15850660754 |
| Website: |
http://www.xinyanpomei.com |
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