| Identification | Back Directory | [Name]
THP-PEG4 | [CAS]
60221-37-6 | [Synonyms]
THP-PEG4
THP-PEG3-OH
OH-PEG3-THP
8-(1H-tetrahydropyran-2-yloxy)-3n63-dioxaoctan-1-ol
2-(2-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethanol
Ethanol, 2-[2-[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethoxy]ethoxy]-
2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol | [Molecular Formula]
C11H22O5 | [MDL Number]
MFCD28976687 | [MOL File]
60221-37-6.mol | [Molecular Weight]
234.29 |
| Hazard Information | Back Directory | [Description]
THP-PEG4 is PEG linker containing a THP protecting group and a terminal hydroxyl. THP is an acid labile, alcohol protecting group. The hydroxyl group can react to further derivatize the compound. The hydrophilic PEG chain increases the water solubility of the compound in aqueous environments. The water solubility properties of the PEG linker are enhanced with longer PEG chains. | [Uses]
THP-PEG3-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005 |
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| Company Name: |
Bide Pharmatech Ltd.
|
| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
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