| Identification | Back Directory | [Name]
THP-SS-alcohol | [CAS]
877864-04-5 | [Synonyms]
THP-SS-alcohol
Ethanol, 2-[[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]dithio]- | [Molecular Formula]
C9H18O3S2 | [MDL Number]
MFCD28505568 | [MOL File]
877864-04-5.mol | [Molecular Weight]
238.37 |
| Hazard Information | Back Directory | [Description]
THP-SS-alcohol is a cleavable linker contains a THP alcohol protecting group and a disulfide bond. The disulfide bonds can be cleaved by using Dithiothreitol (DTT) reagent. The THP protecting group can be removed under acidic conditions. | [Uses]
THP-SS-alcohol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. | [IC 50]
Disulfide Cleavable Linker; Cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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