| Identification | Back Directory | [Name]
Hydroxy-PEG5-t-butyl acetate | [CAS]
1807530-05-7 | [Synonyms]
OH-PEG5-CH2COOtBu
Hydroxy-PEG4-O-Boc
Hydroxy-PEG5-CH2COOtBu
Hydroxy-PEG5-t-butyl acetate
tert-butyl 17-hydroxy-3,6,9,12,15-pentaoxaheptadecanoate
tert-butyl 17-hydroxy-3,6,9,12,15-pentaoxaheptadecan-1-oate
tert-Butyl 17-Hydroxy-3,6,9,12,15-pentaoxa-1-heptadecanoate
3,6,9,12,15-Pentaoxaheptadecanoic acid, 17-hydroxy-, 1,1-dimethylethyl ester
[2-(2-{2-[2-(2-Hydroxyethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid tert-butyl ester | [Molecular Formula]
C16H32O8 | [MDL Number]
MFCD27977509 | [MOL File]
1807530-05-7.mol | [Molecular Weight]
352.42 |
| Chemical Properties | Back Directory | [Boiling point ]
432.4±40.0 °C(Predicted) | [density ]
1.082±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [form ]
Liquid | [pka]
14.36±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Hydroxy-PEG5-CH2CO2tBu is a PEG linker containing a hydroxyl group with a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Hydroxy-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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