| Identification | Back Directory | [Name]
Hydroxy-PEG6-CH2CO2tBu | [CAS]
297162-47-1 | [Synonyms]
OH-PEG6-CH2COOtBu
Hydroxy-PEG6-CH2-Boc
Hydroxy-PEG6-CH2CO2tBu
Hydroxy-PEG6-CH2COOtBu
Hydroxy-PEG6-t-butyl acetate
tert-butyl 20-hydroxy-3,6,9,12,15,18-hexaoxaicosanoate
3,6,9,12,15,18-Hexaoxaeicosanoic acid, 20-hydroxy-, 1,1-dimethylethyl ester | [Molecular Formula]
C18H36O9 | [MDL Number]
MFCD27977498 | [MOL File]
297162-47-1.mol | [Molecular Weight]
396.47 |
| Chemical Properties | Back Directory | [Boiling point ]
469.5±40.0 °C(Predicted) | [density ]
1.086±0.06 g/cm3(Predicted) | [form ]
Liquid | [pka]
14.36±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Hydroxy-PEG6-CH2CO2tBu is a PEG linker containing a hydroxyl group with a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Hydroxy-PEG6-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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