| Identification | Back Directory | [Name]
Hydroxy-PEG3-t-butyl acetate | [CAS]
518044-31-0 | [Synonyms]
HO-PEG3-CH2COOtBu
OH-PEG3-CH2COOtBu
Hydroxy-PEG3-CH2-Boc
Hydroxy-PEG3-CH2CO2tBu
Hydroxy-PEG3-CH2COOtBu
Hydroxy-PEG3-t-butyl acetate
tert-butyl 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)acetate
tert-butyl 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)acetate(WXPC0085)
Acetic acid, [2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, 1,1-dimethylethylester
Acetic acid, 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester | [Molecular Formula]
C12H24O6 | [MDL Number]
MFCD27977510 | [MOL File]
518044-31-0.mol | [Molecular Weight]
264.32 |
| Chemical Properties | Back Directory | [Boiling point ]
351.2±27.0 °C(Predicted) | [density ]
1.071±0.06 g/cm3(Predicted) | [form ]
viscous liquid | [pka]
14.36±0.10(Predicted) | [color ]
Colourless | [InChI]
InChI=1S/C12H24O6/c1-12(2,3)18-11(14)10-17-9-8-16-7-6-15-5-4-13/h13H,4-10H2,1-3H3 | [InChIKey]
YZXRUQCLSBHYHG-UHFFFAOYSA-N | [SMILES]
C(OC(C)(C)C)(=O)COCCOCCOCCO |
| Hazard Information | Back Directory | [Description]
Hydroxy-PEG3-CH2CO2tBu is a PEG linker containing a hydroxyl group with a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Hydroxy-PEG3-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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