| Identification | Back Directory | [Name]
Bromo-PEG2-CH2CO2tBu | [CAS]
1807518-63-3 | [Synonyms]
CAS_1807518-63-3
Br-PEG2-CH2COOtBu
Bromo-PEG2-CH2-Boc
Bromo-PEG2-CH2CO2tBu
Bromo-PEG2-CH2COOtBu
t-butyl acetate-PEG2-bromide
t-butyl acetate-PEG2-bromiade
tert-Butyl 2-[2-(2-bromoethoxy)ethoxy]acetate
t-butyl acetate-PEG2-bromide
BROMO-PEG2-CH2CO2TBU | [Molecular Formula]
C10H19BrO4 | [MDL Number]
MFCD28122957 | [MOL File]
1807518-63-3.mol | [Molecular Weight]
283.16 |
| Hazard Information | Back Directory | [Description]
Bromo-PEG2-CH2CO2tBu is a PEG linker containing a bromide group and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Bromo-PEG2-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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