| Identification | Back Directory | [Name]
5-Amino-1-methylpyrazole-4-carboxamide | [CAS]
18213-75-7 | [Synonyms]
BUTTPARK 94\04-11
5-AMINO-1-METHYLPYRAZOLE-4-CARBOXAMIDE
5-amino-1-methyl-4-pyrazolecarboxamide
5-AMINO-1-METHYL-1H-PYRAZOLE-4-CARBOXAMIDE
5-Amino-1-methylpyrazole-4-carboxamide, tech
1H-Pyrazole-4-carboxaMide, 5-aMino-1-Methyl-
5-Amino-1,3-dimethyl-1H-pyrazole-4-carboxamide
5-Amino-1-methyl-1h-pyrazole-4-carboxamide, tech
1H-Pyrazole-4-carboxamide,5-amino-1-methyl-(9CI)
5-AMINO-1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID AMIDE
3-imino-2-methyl-2,3-dihydro-1H-pyrazole-4-carboxamide
5-amino-1-methyl-1H-pyrazole-4-carboxamide(SALTDATA: FREE)
5-Amino-4-carbamoyl-1-methyl-1H-pyrazole, 5-Amino-4-(aminocarbonyl)-1-methyl-1H-pyrazole | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C5H8N4O | [MDL Number]
MFCD00111808 | [MOL File]
18213-75-7.mol | [Molecular Weight]
140.14 |
| Chemical Properties | Back Directory | [Melting point ]
224-226°C | [Boiling point ]
355.1±22.0 °C(Predicted) | [density ]
1.56±0.1 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
15.26±0.50(Predicted) |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of 5-amino-1-methyl-1H-pyrazole-4-carboxamide from 1-methyl-4-cyano-5-amino-1,2-pyrazole was carried out as follows: a mixture of 1-methyl-4-cyano-5-amino-1,2-pyrazole (0.11 mol) and concentrated sulfuric acid (30 mL, 0.6 mol) was stirred for 1 h at room temperature. Upon completion of the reaction, the mixture was slowly poured into ice water and the pH was adjusted to 8 with 50% aqueous ammonium hydroxide under ice bath conditions.Subsequently, the precipitated solid product was filtered and washed with cold water to give the final 5-amino-1-methyl-1H-pyrazole-4-carboxamide (13.5 g, 91% yield). | [References]
[1] Patent: WO2009/97446, 2009, A1. Location in patent: Page/Page column 64
[2] Patent: WO2009/97446, 2009, A1. Location in patent: Page/Page column 64
[3] Journal of Organic Chemistry, 1956, vol. 21, p. 1240,1242
[4] Patent: EP2025678, 2009, A1. Location in patent: Page/Page column 18-19 |
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