| Identification | More | [Name]
Lithium tert-butoxide | [CAS]
1907-33-1 | [Synonyms]
LITHIUM T-BUTOXIDE
LITHIUM TERT-BUTOXIDE
LITHIUM TERT-BUTYLATE
LTB
2-methyl-2-propanolithiumsalt
2-methyl-2-propanollithiumsalt
lithiumtert-butanolate
tert-butoxylithium
tert-butylalcohol,lithiumsalt
Lithium tert-butoxide solution
Lithiumtbutoxideminoffwhitepowder
lithium 2-methylpropan-2-olate
Lithium t-butoxide, 98+%
LITHIUM TERT-BUTOXIDE SOLUTION, ~1 M IN HEXANE
LITHIUM TERT-BUTOXIDE, 1.0M SOLUTION IN HEXANES
LITHIUM TERT-BUTOXIDE SOLUTION, ~1 M IN THF
LITHIUM TERT-BUTOXIDE, 1.0M SOLUTION IN TETRAHYDROFURAN
LITHIUM-TERT.-BUTYLAT
Lithium tertiary butoxide
Lithiumtert-butoxid | [EINECS(EC#)]
217-611-5 | [Molecular Formula]
C4H9LiO | [MDL Number]
MFCD00050479 | [Molecular Weight]
80.05 | [MOL File]
1907-33-1.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow powder | [Melting point ]
°C | [Boiling point ]
68-70 °C
| [density ]
0.89 g/mL at 20 °C
| [Fp ]
−2 °F
| [storage temp. ]
Flammables area | [solubility ]
Soluble in toluene, hexane, tetrahydrofuran and methyl tert-butyl ether. | [form ]
liquid
| [color ]
brown
| [Specific Gravity]
0.89 | [Water Solubility ]
vigorous reaction | [Hydrolytic Sensitivity]
7: reacts slowly with moisture/water | [Sensitive ]
Moisture Sensitive | [BRN ]
3620018 | [InChI]
1S/C4H9O.Li/c1-4(2,3)5;/h1-3H3;/q-1;+1 | [InChIKey]
LZWQNOHZMQIFBX-UHFFFAOYSA-N | [SMILES]
[Li+].CC(C)(C)[O-] | [CAS DataBase Reference]
1907-33-1(CAS DataBase Reference) | [EPA Substance Registry System]
1907-33-1(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H312-H412 | [Precautionary statements ]
P273-P280-P302+P352+P312-P362+P364-P501 | [Hazard Codes ]
F,C,N | [Risk Statements ]
R11:Highly Flammable.
R19:May form explosive peroxides.
R34:Causes burns.
R37:Irritating to the respiratory system.
R35:Causes severe burns.
R14:Reacts violently with water.
R67:Vapors may cause drowsiness and dizziness.
R65:Harmful: May cause lung damage if swallowed.
R62:Possible risk of impaired fertility.
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R48/20:Harmful: danger of serious damage to health by prolonged exposure through inhalation . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S62:If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label .
S16:Keep away from sources of ignition-No smoking .
S7/8:Keep container tightly closed and dry .
S43:In case of fire, use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add-Never use water) .
S33:Take precautionary measures against static discharges . | [RIDADR ]
UN 3206 4.2/PG 2
| [WGK Germany ]
3
| [RTECS ]
UB8520000
| [F ]
3-10 | [TSCA ]
Yes | [REACH Registrations]
Active | [HazardClass ]
4.2 | [PackingGroup ]
III | [HS Code ]
29051990 | [Storage Class]
4.2 - Pyrophoric and self-heating hazardous materials | [Hazard Classifications]
Acute Tox. 4 Oral
Self-heat. 1
Skin Corr. 1B |
| Hazard Information | Back Directory | [Chemical Properties]
clear yellow to brown solution | [Uses]
Lithium tert-butoxide is a mild base used in organic synthesis. It is involved in the alfa-alkylation reaction of ketones with primary alcohols. It is utilized as a catalyst in the reduction of ketones to the corresponding secondary alcohols. It acts as lithium source utilized in the preparation of LixTiyOz thin films. Further, it is used in conjunction with organometallic reagents/catalysts to modify their reactivity and selectivity. | [reaction suitability]
core: lithium | [Biochem/physiol Actions]
Enterotoxigenic Escherichia coli causes diarrhea through its heat-labile enterotoxin (LT). The LT is a periplasmic protein composed of one A subunit (LTA, 27 kDa) and five non-covalently associated B subunits (LTB, 11.6 kDa each) forming a ring-like pentamer. LTB has high affinity towards the toxin receptor ganglioside GM1, a glycosphingolipid found ubiquitously on the surface of mammalian cells. Ganglioside GM1 facilitates the delivery of the A subunit to the cytosol of the target cell resulting in persistent synthesis of cAMP and subsequently diarrhea. This characteristic makes LTB a good label for microglial cells (due to the enrichment of ganglioside GM1 on their cell surface). In addition, studies made mostly with animal models demonstrated that recombinant LTB could stimulate strong serum and mucosal immune responses against LT. Other studies have indicated that LTB could be used as a potent mucosal adjuvant. | [Safety]
Lithium tert-butoxide is dangerous because it catches fire immediately in contact with air. A few precautions will reduce the risk: Use protection when handling hazardous chemicals, always wear lab coats and safety glasses; Because tert-butyl lithium will automatically react with atmospheric moisture, so avoid its exposure to the atmosphere; Don't work alone and remember how to handle an emergency. |
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Alfa Aesar
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Energy Chemical
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