| Identification | More | [Name]
Nicotinamide-N-oxide | [CAS]
1986-81-8 | [Synonyms]
1-OXY-NICOTINAMIDE
3-(AMINOCARBONYL)PYRIDINIUM-1-OLATE
AKOS 94294
NICOTINAMIDE 1-OXIDE
NICOTINAMIDE N-OXIDE
TIMTEC-BB SBB004187
3-Pyridinecarboxamide, 1-oxide
3-Pyridinecarboxamide,1-oxide(9CI)
1-Oxidopyridin-1-ium-3-carboxamide
Nicotinamide-N-oxide ,98%
3-Carbamoylpyridine 1-oxide
3-Pyridinecarbamide 1-oxide | [EINECS(EC#)]
217-859-4 | [Molecular Formula]
C6H6N2O2 | [MDL Number]
MFCD00006202 | [Molecular Weight]
138.12 | [MOL File]
1986-81-8.mol |
| Chemical Properties | Back Directory | [Appearance]
WHITE TO SLIGHTLY YELLOW FLUFFY CRYST. NEEDLES | [Melting point ]
291-293 °C (dec.)(lit.) | [Boiling point ]
253.51°C (rough estimate) | [density ]
1.3471 (rough estimate) | [refractive index ]
1.5100 (estimate) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
DMSO (Slightly, Heated), Methanol (Slightly, Heated) | [form ]
Solid | [pka]
14.38±0.50(Predicted) | [color ]
White to Off-White | [Sensitive ]
Hygroscopic | [Detection Methods]
HPLC,NMR | [Major Application]
pharmaceutical small molecule | [InChI]
1S/C6H6N2O2/c7-6(9)5-2-1-3-8(10)4-5/h1-4H,(H2,7,9) | [InChIKey]
USSFUVKEHXDAPM-UHFFFAOYSA-N | [SMILES]
NC(=O)c1ccc[n+]([O-])c1 | [CAS DataBase Reference]
1986-81-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [HS Code ]
29339900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Description]
Nicotinamide N-oxide is a metabolite of nicotinamide (Item No. 11127).1 It is formed via oxidation of nicotinamide by the cytochrome P450 (CYP) isoform CYP2E1. Nicotinamide N-oxide (30 mM) inhibits proliferation and induces reduction of nitroblue tetrazolium (NBT; Item No. 17341), indicating cell differentiation, in HL-60 promyelocytic leukemia cells.2 Urine levels of nicotinamide N-oxide are elevated in a mouse model of high-fat diet-induced obesity.3 | [Chemical Properties]
WHITE TO SLIGHTLY YELLOW FLUFFY CRYST. NEEDLES | [Uses]
A metabolite of Nicotinamide | [Uses]
A metabolite of Nicotinamide. | [Definition]
ChEBI: Nicotinamide N-oxide is a member of pyridines. | [References]
[1] ALEXANDER MICHAEL REAL P P Shangyu Hong. Nicotinamide N-oxidation by CYP2E1 in human liver microsomes.[J]. Drug Metabolism and Disposition, 2013, 41 3: 550-553. DOI: 10.1124/dmd.112.049734
[2] KEIKO IWATA. Induction of differentiation in human promyelocytic leukemia HL-60 cell line by niacin-related compounds.[J]. Bioscience, Biotechnology, and Biochemistry, 2003, 67 5: 1132-1135. DOI: 10.1271/bbb.67.1132
[3] JEE-YOUN JUNG. 1H NMR-based metabolite profiling of diet-induced obesity in a mouse mode.[J]. BMB Reports, 2012, 45 7: 419-424. DOI: 10.5483/bmbrep.2012.45.7.248 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
RYSS TECH LTD
|
| Telephone: |
400-188-0725 +86 21 34310725 13611771617 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15256/0_EN.htm |
|