| Identification | More | [Name]
N-2-Acetylguanine | [CAS]
19962-37-9 | [Synonyms]
2-ACETAMIDO-6-HYDROXYPURINE
2-ACETYLGUANINE
2-N-ACETYLGUANINE
N-2-ACETYLGUANINE
N-ACETYLGUANINE
n-(6,7-dihydro-6-oxo-1h-purin-2-yl)-acetamid
N-(6,7-dihydro-6-oxo-1H-purin-2-yl)acetamide
2-ACETAMIDO-6-HYDROXYPURINE 95+%
2-N-Acetylguanine, 2-Acetamido-6-hydroxypurine
N-(6-Oxo-3,7-dihydropurin-2-yl)acetamide
2-acetylamino-6-hydroxypurine
Acetamide, N-(6,7-dihydro-6-oxo-1H-purin-2-yl)-
N-2-ACETYLGUANINE, 99+%
2-(Acetylamino)-7H-purine-6(1H)-one | [EINECS(EC#)]
243-443-7 | [Molecular Formula]
C7H7N5O2 | [MDL Number]
MFCD00078201 | [Molecular Weight]
193.16 | [MOL File]
19962-37-9.mol |
| Chemical Properties | Back Directory | [Appearance]
White Crystalline | [Melting point ]
260 °C | [Boiling point ]
329.37°C (rough estimate) | [density ]
1.4225 (rough estimate) | [refractive index ]
1.8000 (estimate) | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [solubility ]
DMSO (Slightly) | [form ]
Powder | [pka]
9.06±0.20(Predicted) | [color ]
White to beige | [Water Solubility ]
practically insoluble | [CAS DataBase Reference]
19962-37-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S24/25:Avoid contact with skin and eyes .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [HS Code ]
29335990 |
| Hazard Information | Back Directory | [Chemical Properties]
White Crystalline | [Uses]
Protected guanine | [Synthesis]
The general procedure for the synthesis of N-(6-hydroxy-9H-purin-2-yl)acetamide from guanine is as follows:Example 52 Preparation of N2-acetyl guanine. Guanine (10.1 g) was suspended in N,N-dimethylacetamide (100 ml) followed by the addition of acetic anhydride (20 ml). The reaction mixture was stirred under reflux conditions for 2 h followed by thermal filtration. The filtrate was cooled to room temperature and the precipitated solid was filtered. The solid was suspended in ethanol (66 ml) and stirred for 1.5 hours and then filtered. The resulting solid was placed in 50% ethanol and stirred at reflux for 3 hours, followed by cooling of the solution. The solid product was obtained by filtration, washed with 50% ethanol and dried to give the target compound N2-acetylguanine (9.36 g, 72.7% yield) as a white solid.1H NMR (DMSO-d6) δ 13.14 (broad peak, 1H), 12.14 (broad peak, 1H), 11.67 (broad peak, 1H), 8.10 (broad peak, 1H), 2.28 ( single peak, 3H). | [References]
[1] Patent: US6034087, 2000, A
[2] Organic Letters, 2015, vol. 17, # 20, p. 4933 - 4935 |
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