| Identification | More | [Name]
Flumethasone 21-pivalate | [CAS]
2002-29-1 | [Synonyms]
6a,9a-difluoro-16a-methyl-prednisolone-21-pivalate
6ALPHA,9-DIFLUORO-11BETA,17,21-TRIHYDROXY-16ALPHA-METHYLPREGNA-1,4-DIENE-3,20-DIONE 21-[2,2-DIMETHYLPROPIONATE]
flumethasone 21-pivalate
FLUMETHASONE PIVALATE
21-pivalate
locacorten
locorten
pregna-1,4-diene-3,20-dione,6-alpha,9-difluoro-11-beta,17,21-trihydroxy-16-alp
flumetasone 21-pivalate
Pregna-1,4-diene-3,20-dione, 21-(2,2-dimethyl-1-oxopropoxy)-6,9-difluoro-11,17-dihydroxy-16-methyl-, (6.alpha.,11.beta.,16.alpha.)-
6α,9-difluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-(2,2-dimethylpropionate)
6α,9α-Difluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione 21-pivalate
6α,9α-Difluoro-16α-methylprednisolone 21-pivalate
Lorinden
Losalen
NSC 107680
Pivalic acid, 21-ester with 6α,9-difluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione (8CI)
Pregna-1,4-diene-3,20-dione, 21-(2,2-dimethyl-1-oxopropoxy)-6,9-difluoro-11,17-dihydroxy-16-methyl-, (6α,11β,16α)-
Pregna-1,4-diene-3,20-dione, 6α,9-difluoro-11β,17,21-trihydroxy-16α-methyl-, 21-pivalate (7CI, 8CI)
FLUMETHSONEPIVALATE | [EINECS(EC#)]
217-901-1 | [Molecular Formula]
C27H36F2O6 | [MDL Number]
MFCD00079287 | [Molecular Weight]
494.57 | [MOL File]
2002-29-1.mol |
| Chemical Properties | Back Directory | [Appearance]
White or almost white, crystalline powder. | [Melting point ]
>263°C (dec.) | [Boiling point ]
600.3±55.0 °C(Predicted) | [density ]
1.27±0.1 g/cm3(Predicted) | [storage temp. ]
Refrigerator | [solubility ]
dioxane: soluble4.0ML, clear, colorless to very faintly yellow (50 mg + 4.0 mL dioxane) | [form ]
solid | [pka]
11.86±0.70(Predicted) | [color ]
White to Off-White | [Optical Rotation]
[α]25/D 71.0 to 82.0°, c = 1 in dioxane | [CAS DataBase Reference]
2002-29-1(CAS DataBase Reference) | [EPA Substance Registry System]
2002-29-1(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS08 | [Signal word ]
Warning | [Hazard statements ]
H351 | [Precautionary statements ]
P201-P202-P280-P308+P313-P405-P501 | [Hazard Codes ]
Xn | [Risk Statements ]
R40:Limited evidence of a carcinogenic effect. | [Safety Statements ]
S22:Do not breathe dust .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
TU3832010
| [HS Code ]
2937220000 | [Toxicity]
mouse,LD50,oral,> 5gm/kg (5000mg/kg),Drugs in Japan Vol. 6, Pg. 705, 1982. |
| Hazard Information | Back Directory | [Chemical Properties]
White or almost white, crystalline powder. | [Uses]
An anti-inflammatory anti-itching corticosteroid found in topical creams. | [Uses]
flumethasone pivalate is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. As it is a pivalate, its anti-inflammatory action is concentrated at the site of application. This local effect on diseased areas results in a prompt decrease in inflammation, exudation and itching. | [Definition]
ChEBI: Flumethasone pivalate is a pivalate ester, a glucocorticoid, an 11beta-hydroxy steroid, a 17alpha-hydroxy steroid, a 20-oxo steroid, a fluorinated steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a tertiary alpha-hydroxy ketone. It has a role as an anti-inflammatory drug and an antipruritic drug. It is functionally related to a flumethasone. | [Brand name]
Locorten (Novartis). |
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AFINE CHEMICALS LIMITED
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