201467-81-4

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201467-81-4 Structure

Identification	Back Directory
[Name] N33-TEG-COOH
[CAS] 201467-81-4
[Synonyms] N3-TEG-COOH N33-TEG-COOH N3-PEG4-CH2COOH 14-Azido-3,6,9,12-tetraoxatetradecanoic acid 14-azido-3,6,9,12-tetraoxa-1-tetradecanoic acid 14-Azido-3,6,9,12-tetraoxatetradecanoic acid solution Acetic acid, 2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]- 2-{2-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}ethoxy}acetic acid solution 14-Azido-3,6,9,12-tetraoxatetradecanoic acid solution - 0.5M solution in tert-butyl methyl ether 14-Azido-3,6,9,12-tetraoxatetradecanoic acid solution ~0.5 M in tert-butyl methyl ether, >=90% (HPLC)
[Molecular Formula] C10H19N3O6
[MDL Number] MFCD20134123
[MOL File] 201467-81-4.mol
[Molecular Weight] 277.28

Chemical Properties	Back Directory
[density ] 0.750-0.850 g/mL at 20 °C
[Fp ] -33℃
[storage temp. ] 2-8°C
[form ] Liquid
[color ] Colorless to light yellow
[BRN ] 7928855

Questions And Answer	Back Directory
[Uses] Azido-PEG4-CH2CO2H is a useful research chemical.

Hazard Information	Back Directory
[Description] Azido-PEG4-CH2CO2H is a very popular click chemistry linker containing an azide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU).
[reaction suitability] reaction type: click chemistry reagent type: linker
[IC 50] PEGs
[References] [1] Zengerle M, et al. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS Chem Biol. 2015 Aug 21;10(8):1770-7. DOI:10.1021/acschembio.5b00216

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