| Identification | Back Directory | [Name]
BMT-145027 | [CAS]
2018282-44-3 | [Synonyms]
BMT-145027
BMT145027;BMT 145027
3-[4-chloro-3-(trifluoromethyl)phenyl]-4-cyclopropyl-6-phenyl-2H-pyrazolo[3,4-b]pyridine-5-carbonitrile
1H-Pyrazolo[3,4-b]pyridine-5-carbonitrile, 3-[4-chloro-3-(trifluoromethyl)phenyl]-4-cyclopropyl-6-phenyl- | [Molecular Formula]
C23H14ClF3N4 | [MOL File]
2018282-44-3.mol | [Molecular Weight]
438.83 |
| Chemical Properties | Back Directory | [Boiling point ]
653.2±55.0 °C(Predicted) | [density ]
1.51±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 2.4 mg/mL (5.47 mM) | [form ]
Solid | [pka]
7.40±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
BMT-145027 is an mGluR5 positive allosteric modulator without inherent agonist activity, exhibits an EC50 of 47 nM. | [in vivo]
Drug-treated and control mice are shown two identical objects. After a 24-h natural forgetting period, the mice are reintroduced to a familiar object while simultaneously presented with a novel object. Since mice spend more time exploring unfamiliar objects, improved memory is measured as time spent exploring the novel object. BMT-145027 leads to a significant increase in time spent with the novel object when dosed at 30 mg/kg, with an apparent trend in novel object preference at 10 mg/kg. Satellite animals indicates a total plasma concentration of 2800 nM at 30 mg/kg[1]. | [IC 50]
mGluR5: 47 nM (EC50) | [storage]
Store at -20°C | [References]
[1] Hill MD, et al. Development of 1H-Pyrazolo[3,4-b]pyridines as Metabotropic Glutamate Receptor 5 Positive Allosteric Modulators. ACS Med Chem Lett. 2016 Oct 3;7(12):1082-1086. DOI:10.1021/acsmedchemlett.6b00292 |
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