| Identification | Back Directory | [Name]
Ald--Ph-PEG6-acid | [CAS]
2055013-55-1 | [Synonyms]
CHO-Ph-PEG6-acid
Ald-Ph-PEG6-COOH
Ald--Ph-PEG6-acid
CHO-Ph-CONH-PEG6-acid
Propanoic acid, 3-[[19-(4-formylphenyl)-19-oxo-3,6,9,12,15-pentaoxa-18-azanonadec-1-yl]oxy]- | [Molecular Formula]
C23H35NO10 | [MDL Number]
MFCD22056302 | [MOL File]
2055013-55-1.mol | [Molecular Weight]
485.52 |
| Chemical Properties | Back Directory | [Boiling point ]
682.4±55.0 °C(Predicted) | [density ]
1?+-.0.06 g/cm3(Predicted) | [storage temp. ]
Storage temp. 2-8°C | [solubility ]
Soluble in Water, DMSO, DMF | [form ]
Viscous Liquid | [pka]
4.28±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Ald-Ph-PEG6-acid is an aldehyde PEG reagent. The benzaldehyde group is reactive with hydrazide and aminooxy moiety. The terminal carboxylic acid can couple with primary amines in the presence of activators such as EDC or HATU to form a stable amide bond. PEG6 linker increases the solubility of compounds in aqueous media. | [Uses]
Ald-Ph-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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