| Identification | Back Directory | [Name]
α,ω,-dipropionic acid nonaethylene glycol | [CAS]
2055023-26-0 | [Synonyms]
Bis-PEG10-COOH
HOOCCH2CH2O-PEG9-CH2CH2COOH
α,ω,-dipropionic acid nonaethylene glycol
4,7,10,13,16,19,22,25,28,31-Decaoxatetratriacontanedioic acid | [Molecular Formula]
C24H46O14 | [MDL Number]
MFCD28334514 | [MOL File]
2055023-26-0.mol | [Molecular Weight]
558.61 |
| Chemical Properties | Back Directory | [Boiling point ]
657.7±55.0 °C(Predicted) | [density ]
1.169±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C, sealed storage, away from moisture | [form ]
Liquid | [pka]
3.97±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Bis-PEG10-acid is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | [Uses]
Bis-PEG10-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] Zhao Q, et al. Discovery of SIAIS178 as an Effective BCR-ABL Degrader by Recruiting Von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. J Med Chem. 2019 Oct 24;62(20):9281-9298. DOI:10.1021/acs.jmedchem.9b01264 |
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