| Identification | Back Directory | [Name]
5-Methyl-2-mercaptobenzothiazole | [CAS]
21303-50-4 | [Synonyms]
5-Methyl-2-benzothiazolethiol
5-Methylbenzo[d]thiazole-2-thiol
2-Mercapto-5-methylbenzothiazole
2-Mercapto-5-methyl bezimidazole
5-Methyl-2-mercaptobenzothiazole
5-Methyl-2(3H)-benzothiazolethione
2(3H)-Benzothiazolethione, 5-methyl-
5-methyl-3H-1,3-benzothiazole-2-thione
2(3H)-Benzothiazolethione,5-methyl-(9CI) | [Molecular Formula]
C8H7NS2 | [MDL Number]
MFCD11044825 | [MOL File]
21303-50-4.mol | [Molecular Weight]
181.28 |
| Chemical Properties | Back Directory | [Melting point ]
121 °C | [Boiling point ]
314 °C | [density ]
1.39 | [Fp ]
144 °C | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
9.60±0.20(Predicted) |
| Hazard Information | Back Directory | [Synthesis]
Synthesis of 5-methyl-2-mercaptobenzothiazole (10): 2-chloro-5-methylaniline (9, 1.00 g, 7.06 mmol) and potassium carbonate (K2CO3, 2.80 g, 28.2 mmol) were suspended in N,N-dimethylformamide (DMF, 20 mL) under protection of nitrogen. Subsequently, carbon disulfide (CS2, 0.50 mL, 8.50 mmol) was added to the suspension. The reaction mixture was heated and reacted at 150 °C for 16 hours. Upon completion of the reaction, it was cooled to room temperature, the reaction mixture was diluted with deionized water (30 mL) and acidified with 1 N hydrochloric acid (HCl) to a pH of about 1. The resulting precipitate was collected by filtration, washed several times with deionized water, and finally dried under vacuum in the presence of phosphorus pentoxide (P2O5) to afford the target product 5-methyl-2-mercaptobenzothiazole (10, 0.35 g, Yield 27%). | [References]
[1] Patent: WO2006/122156, 2006, A2. Location in patent: Page/Page column 126 |
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| Company Name: |
Cool Pharm, Ltd
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| Telephone: |
021-60455363 18019463053 |
| Website: |
www.coolpharm.com |
| Company Name: |
BioPharmaMatrix,Inc.
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| Telephone: |
0510-86010668 13395169561; |
| Website: |
http://www.biopharmamatrix.com |
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