| Identification | More | [Name]
5-Chloro-2-hydroxy-3-nitropyridine | [CAS]
21427-61-2 | [Synonyms]
5-CHLORO-2-HYDROXY-3-NITROPYRIDINE
5-CHLORO-3-NITRO-2-PYRIDINOL
5-CHLORO-3-NITROPYRIDIN-2-OL
2-hydroxy-3-nitro-5-chloropyridine
5-Chloro-3-nitropyridin-2-ol, 95+%
5-Chloro-2-hydroxy-3-nitropyridine 95+%
5-Chloro-2-hydroxy-3-nitropyridine ,97% | [EINECS(EC#)]
622-609-6 | [Molecular Formula]
C5H3ClN2O3 | [MDL Number]
MFCD00114884 | [Molecular Weight]
174.54 | [MOL File]
21427-61-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
232-236 °C | [Boiling point ]
284.1±40.0 °C(Predicted) | [density ]
1.61±0.1 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [solubility ]
soluble in Dimethylformamide | [form ]
powder to crystal | [pka]
6.31±0.10(Predicted) | [color ]
Light yellow to Yellow to Green | [Detection Methods]
HPLC | [BRN ]
383852 | [InChI]
1S/C5H3ClN2O3/c6-3-1-4(8(10)11)5(9)7-2-3/h1-2H,(H,7,9) | [InChIKey]
QVGQNICXNZMXQA-UHFFFAOYSA-N | [SMILES]
Oc1ncc(Cl)cc1[N+]([O-])=O | [CAS DataBase Reference]
21427-61-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R41:Risk of serious damage to eyes.
R37/38:Irritating to respiratory system and skin .
R22:Harmful if swallowed. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S39:Wear eye/face protection .
S36:Wear suitable protective clothing . | [WGK Germany ]
3 | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29337900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
White to light brown solid | [Uses]
5-Chloro-2-hydroxy-3-nitropyridine (cas# 21427-61-2) is a compound useful in organic synthesis. | [Synthesis]
Preparation of Example A2 5-chloro-2-hydroxy-3-nitropyridine (STR9): 321 g of 2-amino-5-chloropyridine was slowly added dropwise to 1.25 L of concentrated sulfuric acid with continuous stirring until the raw material was completely dissolved. Subsequently, 172.5 g of sodium nitrite (dissolved in 240 mL of water) was slowly added at 40°C to 45°C and the reaction mixture continued to be stirred for 15 minutes. Next, 125 mL of pure nitric acid was slowly added dropwise over 40 minutes at 50°C. The reaction mixture was maintained at 55°C for 1 hour and then the reaction was quenched by pouring into 5 kg of ice water. The yellow precipitated product was collected by filtration, washed thoroughly with deionized water and dried at 60°C to afford 351 g of 5-chloro-2-hydroxy-3-nitropyridine in 80.5% of the theoretical yield and a melting point of 229°C to 231°C. | [References]
[1] Patent: US5274100, 1993, A
[2] Yakugaku Zasshi, 1952, vol. 72, p. 431
[3] Chem.Abstr., 1953, p. 6404 |
|
|