ChemicalBook--->CAS DataBase List--->22248-79-9

22248-79-9

22248-79-9 Structure

22248-79-9 Structure
IdentificationMore
[Name]

Tetrachlorvinphos
[CAS]

22248-79-9
[Synonyms]

1,2,4-trichloro-5-[2-chloro-1-dimethoxyphosphoryloxy-ethenyl]benzene
2-CHLORO-1-[2,4,5-TRICHLOROPHENYL]-VINYL-DIMETHYLPHOSPHATE
CVMP
DEBANTIC
DIMETHYL-1-[2,4,5-TRICHLOROPHENYL]-2-CHLOROVINYL PHOSPHATE
GARDONA
GARDONA(R)
RABON(R)
Ravap
REVAP(R)
STIRIFOS
STIROFOS
STIROPHOS
TETRACHLORVINPHOS
(z)-2-chloro-1-(2,4,5-trichlorophenyl)ethenylphosphoric acid dimethyl ester
(Z)-2-Chloro-1-(2,4,5-trichlorophenyl)ethenyl dimethyl phosphate
(Z)-2-Chloro-1-(2,4,5-trichlorophenyl)vinyl dimethyl phosphate
2,4,5-trichloro-alpha-(chloromethylene)-benzylalcohodimethylphosphate
2,4,5-trichloro-alpha-(chloromethylene)benzylphosphate
Appex
[EINECS(EC#)]

244-865-4
[Molecular Formula]

C10H9Cl4O4P
[MDL Number]

MFCD00078729
[Molecular Weight]

365.96
[MOL File]

22248-79-9.mol
Chemical PropertiesBack Directory
[Appearance]

Powder.Partially soluble in chloroform; slightly soluble in water.
[Melting point ]

97-98 °C(lit.)
[Boiling point ]

399.5±42.0 °C(Predicted)
[density ]

1.520±0.06 g/cm3(Predicted)
[vapor pressure ]

6.0×10-6 Pa (20 °C)
[storage temp. ]

0-6°C
[form ]

solid
[Water Solubility ]

11mg l-1(20°C)
[Merck ]

13,9267
[CAS DataBase Reference]

22248-79-9(CAS DataBase Reference)
[IARC]

2B (Vol. 30, Sup 7, 112) 2017
[NIST Chemistry Reference]

Tetrachlorvinphos(22248-79-9)
[EPA Substance Registry System]

22248-79-9(EPA Substance)
Safety DataBack Directory
[Hazard Codes ]

Xn,N,F
[Risk Statements ]

R21/22:Harmful in contact with skin and if swallowed .
R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R36:Irritating to the eyes.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R11:Highly Flammable.
[Safety Statements ]

S36:Wear suitable protective clothing .
S60:This material and/or its container must be disposed of as hazardous waste .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S36/37:Wear suitable protective clothing and gloves .
S16:Keep away from sources of ignition-No smoking .
[RIDADR ]

UN 3077 9/PG 3
[RTECS ]

TB9100000
[HS Code ]

29199000
[Hazardous Substances Data]

22248-79-9(Hazardous Substances Data)
[Toxicity]

LD50 in male, female rats (mg/kg): 1100, 1125 orally (Gaines)
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Methanol-->Aluminum chloride-->Sodium Methoxide-->Phosphorus trichloride-->Oxygen-->Pentane-->2,2'-Azobis(2-methylpropionitrile)-->Trichloroethylene-->Trimethyl phosphite-->1,2,4-Trichlorobenzene-->Triphenyl phosphite-->Dichloroacetyl chloride-->2-Chloroacetophenone-->PENTACHLOROBENZENE-->B-15
[Preparation Products]

Methyl bromide-->Fipronil-->LINDANE
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

Tetrachlorvinphos(22248-79-9).msds
Hazard InformationBack Directory
[Description]

Tetrachlorvinphos was initially registered for use in the United States in 1966 for use on various food crops, livestock, and pet animals, and in around buildings. Its use on food crops were voluntarily canceled in the United States in 1987; however, it is used on food crops in developing countries. Tetrachlorvinphos is sold under the trade names Rabon and Gardona.
[Chemical Properties]

Powder.Partially soluble in chloroform; slightly soluble in water.
[Chemical Properties]

Technical tetrachlorvinphos is a tan-to-brown crystalline solid. Tetrachlorvinphos is stable at ,100 C and slowly hydrolyzed at 50°C. Aromatic odor.
Soluble in water at 24°C 15 ppm; limited solubility in most aromatic hydrocarbons.
[Uses]

Insecticide.
[Uses]

Tetrachlorvinphos is commonly used as a feed additive to control flies in livestock and as dusts, sprays, dips, and collar ingredient to control ticks and fleas on domestic pets. It is extensively used in poultry. In horses, its formulations are commonly used as a feed additive (feed-through tetrachlorvinphos) larvicide. In addition, tetrachlorvinphos is also used in the control of public health pests, manure flies associated with livestock, and poultry as a feed additive.
[Uses]

Tetrachlorvinphos is used to control lepidopterous and dipterous larvae in fruit and lepidopterous larvae in cotton, maize, rice, tobacco and vegetables. It is also used against nuisance flies in animal houses, animal ectoparasites and stored product pests.
[Definition]

ChEBI: Tetrachlorvinphos is an alkenyl phosphate, a dialkyl phosphate, an organophosphate insecticide, an organochlorine insecticide and a trichlorobenzene. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, an agrochemical, an EC 3.1.1.8 (cholinesterase) inhibitor and an acaricide. It is functionally related to a 1-phenylethenol.
[Hazard]

Cholinesterase inhibitor. Questionable carcinogen.
[Carcinogenicity]

When rats were given diets with 0, 4250, or 8500 ppm tetrachlorvinphos for 80 weeks, both males and females had a high incidence of thyroid C-cell hyperplasia, and females had increased incidences of adrenal cortical adenomas and thyroid C-cell adenomas .
[Environmental Fate]

Tetrachlorvinphos is nonpersistent in the environment. The primary route of dissipation is through biotic degradation. Based on its use pattern, risks of contamination of groundwater or surface water by tetrachlorvinphos are minimal.
[Metabolic pathway]

The chemical structure of tetrachlorvinphos is very close to that of chlorfenvinphos and the routes of metabolic breakdown have been shown to be very similar. Technical tetrachlorvinphos is usually >95% Z-isomer, unlike chlorfenvinphos which is an E/Z mixture. As with chlorfenvinphos, the major routes of detoxification are by dealkylation and hydrolysis to yield desmethyltetrachlorvinphos and 2,2’,4’,5’- tetrachloroacetophenone plus dimethyl phosphate, respectively. Further metabolism of the chloroacetophenone moiety then leads, via reduction or hydrolysis and glutathione-dependent displacement of the side chain chlorine substituent, to the formation of 1-(2,4,5-trichlophenyl) ethane-l,Z-diol and 1-(2,4,5-trichlorophenyl)ethan-l-owl hich are conjugated with glucose or glucuronic acid to afford the ultimate metabolites. Oxidation of the β carbon atom to give 2,4,5-trichloromandelic acid followed by decarboxylation leads to the formation of 2,4,5-trichlorobenzoic acid which is conjugated with glycine in some mammals as the final metabolite. The metabolic routes were summarised by Beynon et al. (1973).
[Degradation]

Tetrachlorvinphos is hydrolysed slowly in neutral, acidic and slightly alkaline aqueous solutions but hydrolysed rapidly in strongly alkaline solutions to metabolites 3 and 5 (PM). Dureja et al. (1987) reported the photochemical degradation of tetrachlorvinphos in water, ethanol, ether and hexane irradiated with a xenon lamp. In polar solvents, the main product was desmethyltetrachlorvinphos (2), whereas in non-polar solvents such as hexane the reaction yielded dimethyl phosphate (3), 2,4,5-trichloroacet ophenone (4) and 2,2’,4’,5’-tetrachloroacetophenone (5). Interconversion of the Z- and Ε-isomers has been observed on leaves (Beynon and Wright, 1969). These pathways are shown in Scheme 1.
[Toxicity evaluation]

Acute oral LD50 for rats: 4,000-5,000 mg/kg
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

22248-79-9(sigmaaldrich)
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