| Identification | More | [Name]
8-Aminoisoquinoline | [CAS]
23687-27-6 | [Synonyms]
8-AMINOISOQUINOLINE
ISOQUINOLIN-8-AMINE
ISOQUINOLIN-8-YLAMINE
8-Aminoisoquinoline95%
8-Aminoisoquinoline 98%
8-amine-isoquinoline
8-Isoquinolinamine | [EINECS(EC#)]
691-616-4 | [Molecular Formula]
C9H8N2 | [MDL Number]
MFCD00179553 | [Molecular Weight]
144.17 | [MOL File]
23687-27-6.mol |
| Chemical Properties | Back Directory | [Melting point ]
155-157 | [Boiling point ]
335.7±17.0 °C(Predicted) | [density ]
1.210±0.06 g/cm3(Predicted) | [storage temp. ]
Keep Cold | [form ]
Crystalline Powder | [pka]
6.20±0.23(Predicted) | [color ]
Brown | [InChI]
InChI=1S/C9H8N2/c10-9-3-1-2-7-4-5-11-6-8(7)9/h1-6H,10H2 | [InChIKey]
GUSYANXQYUJOBH-UHFFFAOYSA-N | [SMILES]
C1C2=C(C=CC=C2N)C=CN=1 | [CAS DataBase Reference]
23687-27-6(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Brown solid | [Uses]
8-Aminoisoquinoline and its derivatives are used as intermediates for antimalarial drugs in the pharmaceutical field. For example, their structure is similar to the antimalarial drug primaquine. | [Synthesis]
General procedure for the synthesis of 8-aminoisoquinolines from 5-bromo-8-nitroisoquinolines: 5-bromo-8-nitroisoquinolines (1.00 g, 3.95 mmol) were dissolved in methanol (70 mL), and hydrogenation was carried out by adding palladium/activated charcoal (10% Pd, 200 mg) as a catalyst for 18 hr at room temperature and atmospheric pressure. Upon completion of the reaction, the reaction mixture was filtered through Celite to remove the catalyst. The filtrate was concentrated and purified by column chromatography (eluent: ethyl acetate/heptane) to afford the target compound 8-aminoisoquinoline (100 mg, 18% yield) as a greenish-brown solid.1H NMR (DMSO-d6, 400 MHz) δ 9.43 (s, 1H), 8.32 (d, 1H), 7.54 (d, 1H), 7.40 (dd, 1H) , 6.99 (d, 1H), 6.72 (d, 1H), 6.22 (s, 2H). | [References]
[1] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 4, p. 803 - 806
[2] Journal of Medicinal Chemistry, 2005, vol. 48, # 3, p. 744 - 752
[3] Patent: WO2009/130481, 2009, A1. Location in patent: Page/Page column 143
[4] Journal of Medicinal Chemistry, 2005, vol. 48, # 15, p. 4972 - 4982
[5] Patent: WO2006/32851, 2006, A1. Location in patent: Page/Page column 49 |
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