| Identification | Back Directory | [Name]
Chebulic Acid | [CAS]
23725-05-5 | [Synonyms]
Split acid
Chebulic acid
CHEBULIC ACID(SH)
(2S)-[(3S,4S)-3-Carboxy-3,4-dihydro-5,6,7-trihydroxy-1-oxo-1H-2-benzopyran-4-yl]butanedioic acid
(2S)-2-[(3S)-3,4-Dihydro-3α-carboxy-5,6,7-trihydroxy-1-oxo-1H-2-benzopyran-4β-yl]butanedioic acid
Butanedioic acid,[(3S,4S)-3-carboxy-3,4-dihydro-5,6,7-trihydroxy-1-oxo-1H-2-benzopyran-4-yl]-,(2S)- | [Molecular Formula]
C14H12O11 | [MDL Number]
MFCD09264641 | [MOL File]
23725-05-5.mol | [Molecular Weight]
356.24 |
| Chemical Properties | Back Directory | [Boiling point ]
755.9±60.0 °C(Predicted) | [density ]
1.882 | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
2.60±0.40(Predicted) | [color ]
White to off-white | [InChI]
InChI=1S/C14H12O11/c15-5-1-4-7(10(19)9(5)18)8(3(12(20)21)2-6(16)17)11(13(22)23)25-14(4)24/h1,3,8,11,15,18-19H,2H2,(H,16,17)(H,20,21)(H,22,23)/t3-,8-,11-/m0/s1 | [InChIKey]
COZMWVAACFYLBI-XJEVXTIOSA-N | [SMILES]
C(O)(=O)[C@H]([C@H]1C2=C(O)C(O)=C(O)C=C2C(=O)O[C@@H]1C(O)=O)CC(O)=O |
| Questions And Answer | Back Directory | [Description]
Chebulic acid is a phenolic compound isolated from the ripe fruits of Terminalia chebula. This compound possesses an isomer, neochebulic acid. Chebulic acid is a component of transformed ellagitannins such as chebulagic acid or chebulinic acid.
Chebulic acid (CA) isolated from T. chebula, which has been reported for treating asthma, as a potent anti-oxidant resources. Exposure to ambient urban particulate matter (UPM) considered as a risk for cardiopulmonary vascular dysfunction.
| [Bioactivities]
Chebulinic acid showed many bioactivities including inhibition of cancer cell growth, inhibiting the contractile responses of cardiovascular muscles, anti-fungal, anti-bacterial activities etc. In-vitro anti-cancer activity of Chebulinic acid on Colon adenocarcinoma HT-29 cancer cell lines by using MTT cell growth inhibition assay was stuied. The maximum percentage inhibition of cancer cell lines for Chebulinic acid was found to be 41.2% at a dose of 200µg/ml. Chebulinic acid extraction from Terminalia chebula plays a vital role in medicine, biotechnology and various pharmacological activities.
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| Hazard Information | Back Directory | [Uses]
Chebulic acid can be used for the polypharmacology of metabolites of medicinal plants to target SARS-CoV-2. It can also be used as a therapeutic agent to prevent insulin sensitivity and oxidative stress induced dysfunction of beta cells for diabetes. | [in vivo]
Chebulic acid (37.5, 75 and 150 mg/kg; p.o.; once daily for 5 days) is non-toxic to the liver of male ICR mice, protects against CCL4-induced liver injury through Nrf2 signaling and reduces serum ALT and AST levels and liver injury levels, including reduces necrosis and histological improvement[5]. | Animal Model: | Wistar albino rats of ischemia-reperfusion model[1]. | | Dosage: | 25, 50 mg/kg | | Administration: | Oral gavage (p.o.) once a day for 28 days | | Result: | Reduced blood glucose, creatinine, urea nitrogen, glycated hemoglobin, proteinuria, urinary albumin excretion, glomerular filtration rate (GFR), and increased serum insulin and glycogen levels in diabetic rats. |
| [target]
VEGFR | ROS |
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