| Identification | More | [Name]
2,2,2-Trichloroethyl chloroformate | [CAS]
17341-93-4 | [Synonyms]
2,2,2-TRICHLORO-ETHOXYCARBONYL CHLORIDE
2,2,2-TRICHLOROETHYL CHLOROFORMATE
BETA,BETA,BETA-TRICHLOROETHOXYCARBONYL CHLORIDE
CHLOROFORMIC ACID 2,2,2-TRICHLOROETHYL ESTER
2,2,2-Trichloroethyl chloridocarbonate
carbonochloridicacid,2,2,2-trichloroethylester
Formic acid, chloro-, 2,2,2-trichloroethyl ester
Trichloroethyl chloroformate
trichloroethylchloroformate
Chloroformic acid 2,2,2-trichloroethyl ester~2,2,2-Trichloroethoxycarbonyl chloride~TrocCl
2,2,2 TRI CHLOROETHYL CHLOROFORMAT
2,2,2-Trichloroethylchloroformate99%
NALPHA-tert-Butoxycarbonyl-NEPSILON-trifluoroacetyl-D-lysine
(Trichloroethoxy)chloroformate
2,2,2-Trichloroethyl chloroformate ,97%
(2,2,2-Trichloroethoxy)formic acid chloride
(Carbonic acid 2,2,2-trichloroethyl) chloride
Chloridocarbonic acid 2,2,2-trichloroethyl ester
Chloroformic acid 2,2,2-trichloroethyl
2,2,2-trichloroethyl chlorocarbonate | [EINECS(EC#)]
241-363-7 | [Molecular Formula]
C3H2Cl4O2 | [MDL Number]
MFCD00000810 | [Molecular Weight]
211.86 | [MOL File]
17341-93-4.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear light yellow liquid | [Melting point ]
1°C | [Boiling point ]
171-172 °C (lit.) | [density ]
1.539 g/mL at 25 °C(lit.)
| [vapor pressure ]
0.06 psi ( 20 °C)
| [refractive index ]
n20/D 1.471(lit.)
| [Fp ]
>100°C | [storage temp. ]
2-8°C
| [solubility ]
soluble in Chloroform, Ethyl Acetate | [form ]
Liquid | [color ]
Clear light yellow | [Water Solubility ]
Soluble in Ether, Benzene, Chloroform, Ethanol. Insoluble in water. | [Sensitive ]
Moisture Sensitive | [Detection Methods]
GC,NMR | [BRN ]
970619 | [InChIKey]
LJCZNYWLQZZIOS-UHFFFAOYSA-N | [CAS DataBase Reference]
17341-93-4(CAS DataBase Reference) | [NIST Chemistry Reference]
Carbonochloridic acid, 2,2,2-trichloroethyl ester(17341-93-4) | [Storage Precautions]
Store under nitrogen | [EPA Substance Registry System]
17341-93-4(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS05,GHS06 | [Signal word ]
Danger | [Hazard statements ]
H314-H331 | [Precautionary statements ]
P280-P303+P361+P353-P304+P340+P311-P305+P351+P338+P310 | [Hazard Codes ]
T | [Risk Statements ]
R23:Toxic by inhalation.
R34:Causes burns.
R36:Irritating to the eyes. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S7/9:Keep container tightly closed and in a well-ventilated place . | [RIDADR ]
UN 3277 6.1/PG 2
| [WGK Germany ]
3
| [F ]
10-19 | [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
II | [HS Code ]
29159000 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Ethyl acetate-->Dichloromethane-->Toluene-->Pyridine-->Phosgene-->tert-Butyl methyl ether-->Triphosgene-->Magnesium sulfate heptahydrate-->Trichloroethanol | [Preparation Products]
1,1,1,2-Tetrachloroethane-->(αR,βS)-β-(BenzoylaMino)-α-[[(2,2,2-trichloroethoxy)carbonyl]oxy]-benzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodeca-->1,2-Pyrrolidinedicarboxylic acid, 1-(2,2,2-trichloroethyl) ester, (2S)--->2,2,2-trichloroethyl 3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-ylcarbamate |
| Hazard Information | Back Directory | [Chemical Properties]
Clear light yellow liquid | [Uses]
2,2,2-Trichloroethyl chloroformate is used as a protecting reagent for aliphatic and aromatic hydroxyl and amino groups. It is used as derivatizing reagent in gas chromatographic/mass spectrometric determination of a large range of amphetamine-related drugs and ephedrines in plasma, urine and hair samples, during N-demethylation of dextromethorphan. It was used as starting reagent during the synthesis of 6-Nor-9,10-dihydrolysergic acid methyl ester. | [Application]
2,2,2-Trichloroethyl chloroformate is a protecting agent for various functional groups; a net carboxylating agent for organometallic reagents; achieves N-demethylation and N-debenzylation of tertiary amines; and activates N-heteroaromatic rings for reaction with organostannanes. | [Preparation]
2,2,2-Trichloroethyl chloroformate is widely available commercially. It can be readily prepared by passing Phosgene into a solution of 2,2,2- Trichloroethanol in benzene/diethylaniline or benzene/ether/pyridine. An alternate two-step approach (93% yield) has been described that employs S-Ethyl Chlorothioformate instead of phosgene. |
| Spectrum Detail | Back Directory | [Spectrum Detail]
2,2,2-Trichloroethyl chloroformate(17341-93-4)MS
2,2,2-Trichloroethyl chloroformate(17341-93-4)1HNMR
2,2,2-Trichloroethyl chloroformate(17341-93-4)13CNMR
2,2,2-Trichloroethyl chloroformate(17341-93-4)IR1
2,2,2-Trichloroethyl chloroformate(17341-93-4)Raman
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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