| | Identification | More |  | [Name] 
 2,2,2-Trichloroethyl chloroformate
 |  | [CAS] 
 17341-93-4
 |  | [Synonyms] 
 2,2,2-TRICHLORO-ETHOXYCARBONYL CHLORIDE
 2,2,2-TRICHLOROETHYL CHLOROFORMATE
 BETA,BETA,BETA-TRICHLOROETHOXYCARBONYL CHLORIDE
 CHLOROFORMIC ACID 2,2,2-TRICHLOROETHYL ESTER
 2,2,2-Trichloroethyl chloridocarbonate
 carbonochloridicacid,2,2,2-trichloroethylester
 Formic acid, chloro-, 2,2,2-trichloroethyl ester
 Trichloroethyl chloroformate
 trichloroethylchloroformate
 Chloroformic acid 2,2,2-trichloroethyl ester~2,2,2-Trichloroethoxycarbonyl chloride~TrocCl
 2,2,2 TRI CHLOROETHYL CHLOROFORMAT
 2,2,2-Trichloroethylchloroformate99%
 NALPHA-tert-Butoxycarbonyl-NEPSILON-trifluoroacetyl-D-lysine
 (Trichloroethoxy)chloroformate
 2,2,2-Trichloroethyl chloroformate ,97%
 (2,2,2-Trichloroethoxy)formic acid chloride
 (Carbonic acid 2,2,2-trichloroethyl) chloride
 Chloridocarbonic acid 2,2,2-trichloroethyl ester
 Chloroformic acid 2,2,2-trichloroethyl
 2,2,2-trichloroethyl chlorocarbonate
 |  | [EINECS(EC#)] 
 241-363-7
 |  | [Molecular Formula] 
 C3H2Cl4O2
 |  | [MDL Number] 
 MFCD00000810
 |  | [Molecular Weight] 
 211.86
 |  | [MOL File] 
 17341-93-4.mol
 | 
 | Chemical Properties | Back Directory |  | [Appearance] 
 Clear light yellow liquid
 |  | [Melting point ] 
 1°C
 |  | [Boiling point ] 
 171-172 °C (lit.)
 |  | [density ] 
 1.539 g/mL at 25 °C(lit.)
 
 |  | [vapor pressure ] 
 0.06 psi ( 20 °C)
 
 |  | [refractive index ] 
 n20/D 1.471(lit.)
 
 |  | [Fp ] 
 >100°C
 |  | [storage temp. ] 
 2-8°C
 
 |  | [solubility ] 
 soluble in Chloroform, Ethyl Acetate
 |  | [form ] 
 Liquid
 |  | [color ] 
 Clear light yellow
 |  | [Water Solubility ] 
 Soluble in Ether, Benzene, Chloroform, Ethanol. Insoluble in water.
 |  | [Sensitive ] 
 Moisture Sensitive
 |  | [Detection Methods] 
 GC,NMR
 |  | [BRN ] 
 970619
 |  | [InChIKey] 
 LJCZNYWLQZZIOS-UHFFFAOYSA-N
 |  | [CAS DataBase Reference] 
 17341-93-4(CAS DataBase Reference)
 |  | [NIST Chemistry Reference] 
 Carbonochloridic acid, 2,2,2-trichloroethyl ester(17341-93-4)
 |  | [Storage Precautions] 
 Store under nitrogen
 |  | [EPA Substance Registry System] 
 17341-93-4(EPA Substance)
 | 
 | Safety Data | Back Directory |  | [Hazard Codes ] 
 T
 |  | [Risk Statements ] 
 R23:Toxic by inhalation.
 R34:Causes burns.
 R36:Irritating to the eyes.
 |  | [Safety Statements ] 
 S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
 S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
 S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
 S7/9:Keep container tightly closed and in a well-ventilated place .
 |  | [RIDADR ] 
 UN 3277 6.1/PG 2
 
 |  | [WGK Germany ] 
 3
 
 |  | [F ] 
 10-19
 |  | [TSCA ] 
 Yes
 |  | [HazardClass ] 
 6.1
 |  | [PackingGroup ] 
 II
 |  | [HS Code ] 
 29159000
 | 
 | Raw materials And Preparation Products | Back Directory |  | [Raw materials] 
 Ethyl acetate-->Dichloromethane-->Toluene-->Pyridine-->PHOSGENE-->tert-Butyl methyl ether-->Triphosgene-->Magnesium sulfate heptahydrate-->Trichloroethanol
 |  | [Preparation Products] 
 1,1,1,2-TETRACHLOROETHANE-->(αR,βS)-β-(BenzoylaMino)-α-[[(2,2,2-trichloroethoxy)carbonyl]oxy]-benzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodeca-->1,2-Pyrrolidinedicarboxylic acid, 1-(2,2,2-trichloroethyl) ester, (2S)--->2,2,2-trichloroethyl 3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-ylcarbamate
 | 
 | Hazard Information | Back Directory |  | [Chemical Properties] 
 Clear light yellow liquid
 |  | [Uses] 
 2,2,2-Trichloroethyl chloroformate is used as a protecting reagent for aliphatic and aromatic hydroxyl and amino groups. It is used as derivatizing reagent in gas chromatographic/mass spectrometric determination of a large range of amphetamine-related drugs and ephedrines in plasma, urine and hair samples, during N-demethylation of dextromethorphan. It was used as starting reagent during the synthesis of 6-Nor-9,10-dihydrolysergic acid methyl ester.
 |  | [Application] 
 2,2,2-Trichloroethyl chloroformate is a protecting agent for various functional groups; a net carboxylating agent for organometallic reagents; achieves N-demethylation and N-debenzylation of tertiary amines; and activates N-heteroaromatic rings for reaction with organostannanes.
 |  | [Preparation] 
 2,2,2-Trichloroethyl chloroformate is widely available commercially. It can be readily prepared by passing Phosgene into a solution of 2,2,2- Trichloroethanol in benzene/diethylaniline or benzene/ether/pyridine. An alternate two-step approach (93% yield) has  been described that employs S-Ethyl Chlorothioformate instead of phosgene.
 | 
 | Spectrum Detail | Back Directory |  | [Spectrum Detail] 
 2,2,2-Trichloroethyl chloroformate(17341-93-4)MS
 2,2,2-Trichloroethyl chloroformate(17341-93-4)1HNMR
 2,2,2-Trichloroethyl chloroformate(17341-93-4)13CNMR
 2,2,2-Trichloroethyl chloroformate(17341-93-4)IR1
 2,2,2-Trichloroethyl chloroformate(17341-93-4)Raman
 
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