| Identification | More | [Name]
2,4-DIFLUOROPYRIMIDINE | [CAS]
2802-61-1 | [Synonyms]
2,4-DIFLUOROPYRIMIDINE
Pyrimidine, 2,4-difluoro-(6CI,8CI,9CI)
2,4-Difluoropyrimidine 98%
2,4-Difluoropyrimidine98% | [EINECS(EC#)]
631-074-8 | [Molecular Formula]
C4H2F2N2 | [MDL Number]
MFCD04972830 | [Molecular Weight]
116.07 | [MOL File]
2802-61-1.mol |
| Chemical Properties | Back Directory | [Boiling point ]
118-120 °C | [density ]
1.359 g/mL at 25 °C
| [refractive index ]
n20/D 1.432
| [Fp ]
106 °F
| [storage temp. ]
Storage temp. 2-8°C | [form ]
liquid | [pka]
-2.52±0.20(Predicted) | [color ]
Clear, colourless | [InChI]
1S/C4H2F2N2/c5-3-1-2-7-4(6)8-3/h1-2H | [InChIKey]
JZSYSXZDIQUOGP-UHFFFAOYSA-N | [SMILES]
Fc1ccnc(F)n1 | [CAS DataBase Reference]
2802-61-1(CAS DataBase Reference) |
| Questions And Answer | Back Directory | [Synthesis]
Crown ethers are able to enhance the performance of KF in two ways. Firstly,
they complex the potassium cation making a better fluoride source and secondly they
increase the solubility of KF in the solvent.
KF with a catalytic amount of dicyclohexano-18-crown-6 in tetraglyme converted
2,4-dichloropyrimidine into 2,4-difluoropyrimidine.
 |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R10:Flammable.
R22:Harmful if swallowed.
R37/38:Irritating to respiratory system and skin .
R41:Risk of serious damage to eyes. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S39:Wear eye/face protection . | [RIDADR ]
UN 1993 3/PG 3
| [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29335990 | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Dam. 1
Flam. Liq. 3
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Uses]
2,4-Difluoropyrimidine can be used as a starting material to synthesize:
- 3-Pyrimidin-4-yl-oxazolidin-2-one derivatives as mutant isocitrate dehydrogenase (IDH1) inhibitors.
- N,N′-(1,4-phenylenebis(methylene))bis(2-fluoropyrimidin-4-amine) as chemokine receptor type 4 antagonists.
| [Synthesis Reference(s)]
Journal of Heterocyclic Chemistry, 22, p. 149, 1985 DOI: 10.1002/jhet.5570220137 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Struchem Co., Ltd.
|
| Telephone: |
0512-63009836 18994340901 |
| Website: |
http://www.beidapharma.com |
|