| Identification | More | [Name]
3,5-Difluoropyridine | [CAS]
71902-33-5 | [Synonyms]
3,5-DIFLUOROPYRIDINE
3,5-Difluoropyridine 98%
3,5-Difluoropyridine98%
3,5-Difluropyridine | [EINECS(EC#)]
624-636-9 | [Molecular Formula]
C5H3F2N | [MDL Number]
MFCD03412222 | [Molecular Weight]
115.08 | [MOL File]
71902-33-5.mol |
| Chemical Properties | Back Directory | [Boiling point ]
92-93°C | [density ]
1,268 g/cm3 | [refractive index ]
1.4437 | [Fp ]
9°C | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [form ]
clear liquid | [pka]
0.39±0.20(Predicted) | [color ]
Colorless to Almost colorless | [BRN ]
7914363 | [InChI]
InChI=1S/C5H3F2N/c6-4-1-5(7)3-8-2-4/h1-3H | [InChIKey]
WRXAZPPGFLETFR-UHFFFAOYSA-N | [SMILES]
C1=NC=C(F)C=C1F | [CAS DataBase Reference]
71902-33-5(CAS DataBase Reference) |
| Questions And Answer | Back Directory | [Synthesis]
Hydrogenolysis of 2,4,6-tribromo-3,5-difluoropyridine occurred rapidly giving
quantitative conversion to 3,5-difluoropyridine (5), with an isolated yield by distillation
of 63%.
 |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,F,N,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R50:Very Toxic to aquatic organisms.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R11:Highly Flammable. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S36/37:Wear suitable protective clothing and gloves . | [RIDADR ]
1993 | [WGK Germany ]
3 | [Hazard Note ]
Highly Flammable/Irritant | [HazardClass ]
3 | [PackingGroup ]
II | [HS Code ]
29333990 | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Aquatic Acute 1
Aquatic Chronic 1
Eye Irrit. 2
Flam. Liq. 2
Skin Irrit. 2
STOT SE 3 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Diethyl ether-->Lithium Aluminum Hydride-->Pentafluoropyridine-->2,3,5,6-Tetrafluoropyridine-->3,5-Dichloropyridine-->Potassium fluoride-->Sulfolane | [Preparation Products]
3,5-Difluoro-pyridin-4-ylamine-->2,5-Difluoropyridine-->3,4,5-Trifluoropyridine-->3,5-Difluoro-4-pyridinecarboxaldehyde-->3,5-Dimethoxypyridine-->2,3,4,5-Tetrafluoropyridine |
| Hazard Information | Back Directory | [Chemical Properties]
Liquid | [Preparation]
Synthesis of 3,5-Difluoropyridine: A solution of 2,4,6-tribromo-3,5-difluoropyridine (11) (34.0 g, 97 mmol) in DCM (200 cm3) was washed with activated carbon and filtered. A palladium catalyst (3.4 g of a 5% Pd/C commercially available product) and triethylamine (45 cm3, 31.5 g, 312 mmol) were added to the filtrate and the mixture hydrogenated in a Parr apparatus at 4 Bar for 21 h. The mixture was filtered, water (200 cm3) added and extracted into DCM. Distillation of the DCM solution on Fischer-Spaltrohr apparatus gave 3,5-difluoropyridine (7.0 g, 61 mmol, 63%), b.p. 92.5 ·c (Found: C, 52.2; H, 3.0; N, 12.2. C5H3F2N2 requires C, 52.2; H, 3.0; N, 12.2%);
IR spectrum no. 1; mass spectrum no. 1; nrnr spectrum no. 8. | [References]
[1] Patent: US2006/9643, 2006, A1. Location in patent: Page/Page column 4-5 |
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