| Identification | More | [Name]
3-Amino-4-methylphenol | [CAS]
2836-00-2 | [Synonyms]
2-AMINO-4-HYDROXYTOLUENE
3-AMINO-4-METHYLPHENOL
3-amino-p-cresol
5-Hydroxy-o-toluidine
5-Hydroxy-2-methylaniline
m-Amino-p-cresol
Phenol, 3-amino-4-methyl- | [EINECS(EC#)]
220-622-8 | [Molecular Formula]
C7H9NO | [MDL Number]
MFCD00075083 | [Molecular Weight]
123.15 | [MOL File]
2836-00-2.mol |
| Hazard Information | Back Directory | [General Description]
Crystals. | [Reactivity Profile]
3-AMINO-4-METHYLPHENOL(2836-00-2) reacts with strong oxidizing agents. | [Air & Water Reactions]
3-AMINO-4-METHYLPHENOL may be sensitive to prolonged exposure to air. | [Fire Hazard]
Flash point data for this chemical are not available. 3-AMINO-4-METHYLPHENOL is probably combustible. | [Synthesis]
The general procedure for the synthesis of 3-amino-4-methylphenol from 4-methyl-3-nitrophenol was as follows: 4-methyl-3-nitrophenol (77 mg, 0.50 mmol), Fe nanoparticles (6 mg), and NaBH4 (29 mg, 0.75 mmol) were placed in 1.0 mL of 2 wt. % TPGS/H2O solution, and the reaction was carried out for 2 h at room temperature. Upon completion of the reaction, 56 mg (91% yield) of 3-amino-4-methylphenol was obtained as a white solid (hexane/ethyl acetate = 50:50). The melting point of the product was 154°C-156°C. It was analyzed by GC-MS with m/z of 123 [M], and the spectral data were consistent with those reported in the literature. | [References]
[1] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 1, p. 240 - 244
[2] Green Chemistry, 2017, vol. 19, # 3, p. 809 - 815
[3] Journal of Medicinal Chemistry, 2010, vol. 53, # 5, p. 1964 - 1978
[4] ACS Catalysis, 2017, vol. 7, # 4, p. 2412 - 2418
[5] Patent: WO2018/208132, 2018, A1. Location in patent: Paragraph 704-708 |
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