| Identification | More | [Name]
6-Acetyl-1,4-benzodioxane | [CAS]
2879-20-1 | [Synonyms]
1-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)ETHAN-1-ONE
1-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)ETHANONE
1-(2,3-DIHYDROBENZO[B][1,4]DIOXIN-7-YL)ETHANONE
1,4-BENZODIOXAN-6-YL METHYL KETONE
3',4'-ETHYLENEDIOXYACETOPHENONE
6-ACETYL-1,4-BENZODIOXANE
AKOS BBS-00006494
ASISCHEM D29259
AURORA 18707
1,4-Benzodioxan-6-yl methyl ketone~3,4-Ethylenedioxyacetophenone
1-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-ethanone
Ethanone, 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-
6-Acetyl-2,3-dihydro-1,4-benzodioxin | [EINECS(EC#)]
220-726-3 | [Molecular Formula]
C10H10O3 | [MDL Number]
MFCD00006823 | [Molecular Weight]
178.18 | [MOL File]
2879-20-1.mol |
| Chemical Properties | Back Directory | [Appearance]
ALMOST WHITE TO SLIGHTLY BLUE FINE CRYST. NEEDLES | [Melting point ]
80-82 °C (lit.) | [Boiling point ]
270.41°C (rough estimate) | [density ]
1.1601 (rough estimate) | [refractive index ]
1.5370 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly) | [form ]
Fine Crystalline Needles | [color ]
Almost white to slightly blue | [BRN ]
164125 | [InChI]
1S/C10H10O3/c1-7(11)8-2-3-9-10(6-8)13-5-4-12-9/h2-3,6H,4-5H2,1H3 | [InChIKey]
HGVWMTAIIYNQSI-UHFFFAOYSA-N | [SMILES]
CC(=O)c1ccc2OCCOc2c1 | [CAS DataBase Reference]
2879-20-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Safety Statements ]
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [HazardClass ]
IRRITANT | [HS Code ]
29145090 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Chemical Properties]
ALMOST WHITE TO SLIGHTLY BLUE FINE CRYST. NEEDLES | [Uses]
1,4-Benzodioxan-6-yl methyl ketone may be used in the preparation of acetylenic alcohols. | [Definition]
ChEBI: 1-(2,3-Dihydro-1,4-benzodioxin-6-yl)ethan-1-one is a benzodioxine. | [Synthesis]
GENERAL METHODS: Method B: To a stirred solution of 1-(2,3-dihydrobenzo[B][1,4]dioxin-6-yl)ethan-1-ol (4a, 1.65 g, 9.94 mmol) in anhydrous dichloromethane (100 mL) was added Dess-Martin's reagent (5.06 g, 11.93 mmol) at 0 °C and under argon protection. After 10 minutes of reaction, the mixture was slowly warmed to room temperature and stirring was continued for 16 hours. After completion of the reaction, the reaction was quenched with saturated sodium bicarbonate solution and filtered to remove the insoluble salt. The filtrate was extracted with dichloromethane, the combined organic layers were dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. Finally, the target product 6-acetyl-1,4-benzodioxane (5a, 1.42 g, 87% yield) was purified by silica gel column chromatography with dichloromethane as eluent to give a light yellow solid. | [References]
[1] European Journal of Medicinal Chemistry, 2015, vol. 105, p. 80 - 105 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|