| Identification | Back Directory | [Name]
(3S)-N-Boc-2-azabicyclo[2.2.1]heptane-3-carboxylic acid | [CAS]
291775-59-2 | [Synonyms]
LED-C-3
Ledipasvir INT 2
Ledipasvir Impurity 14
(3S)-N-Boc-2-azabicyclo[2.2.1]heptane-3-carboxylic acid
(1R,3S,4S)-N-Boc-2-azabicyclo[2.2.1]heptane-3-carboxylic acid
(1R,3S,4S)-N-Boc-2-azabicyclo[2.2.1]heptane-3-carboxylic acid 97%
(3S)-N-Boc-2-azabicyclo[2.2.1]heptane-3-carboxylic acid ISO 9001：2015 REACH
(1R,3S,4S)-2-Azabicyclo[2.2.1]heptane-2,3-dicarboxylic acid 2-tert-butyl ester
(1R,3S,4S)-N-(Tert-butoxycarbonyl)-2-azabicyclo-[2.2.1]-heptane-3-carboxylic acid
(1R,3S,4S)-3-[(2-methylpropoxy)carbonyl]-2-azabicyclo[2.2.1]heptane-2-carboxylic acid
2-Azabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, 2-(1,1-diMethylethyl) ester, (1R,3S,4S)- | [EINECS(EC#)]
808-164-2 | [Molecular Formula]
C12H19NO4 | [MDL Number]
MFCD11099876 | [MOL File]
291775-59-2.mol | [Molecular Weight]
241.28 |
| Chemical Properties | Back Directory | [Melting point ]
147-152 °C | [Boiling point ]
371.0±25.0 °C(Predicted) | [density ]
1.232±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
powder | [pka]
4.05±0.20(Predicted) | [Optical Rotation]
[α]22/D -170±10°, c = 1 in chloroform | [InChI]
InChI=1S/C12H19NO4/c1-12(2,3)17-11(16)13-8-5-4-7(6-8)9(13)10(14)15/h7-9H,4-6H2,1-3H3,(H,14,15)/t7-,8+,9-/m0/s1 | [InChIKey]
IFAMSTPTNRJBRG-YIZRAAEISA-N | [SMILES]
[C@]12([H])C[C@]([H])(CC1)[C@@H](C(O)=O)N2C(OC(C)(C)C)=O |
| Hazard Information | Back Directory | [Uses]
(1R,3S,4S)-2-(tert-Butoxycarbonyl)-2-azabicyclo[2.2.1]heptane-3-carboxylic Acid is a building block in the synthesis of Ledipasvir, a potent, once-??daily oral NS5A inhibitor for the treatment of Hepatitis C Virus infection. It is also used to prepare potent direct inhibitors of factor Xa which carries significant promise for developing effective and safe anticoagulants. |
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