| Identification | More | [Name]
4-Chlorobutanal dimethyl acetal | [CAS]
29882-07-3 | [Synonyms]
4-chloro-1,1-dimethoxybutane
4-CHLOROBUTANAL DIMETHYL ACETAL
4-CHLOROBUTYRALDEHYDE DIMETHYL ACETAL
4-CHLORO BUTYALDEHYDE DIMETHYL ACETAL
4-CHLOROBUTANAL DIMETHYL ACETAL (FOR SUMATRIPTAN AND OTHER TRIPTANS)
1-Chloro-4,4-dimethoxybutane
4,4-Dimethoxybutyl Chloride
4-Chlorobutanal Dimethyl Acetal 90%
4-Chlorobutyraldehyde Dimethyl Aceta
4-CHLOROBUTANAL DIMETHYL ACETAL (FOR SUMATRIPTAN AND OTHER TRIPTANS),96.0% | [EINECS(EC#)]
249-924-8 | [Molecular Formula]
C6H13ClO2 | [MDL Number]
MFCD01632883 | [Molecular Weight]
152.62 | [MOL File]
29882-07-3.mol |
| Chemical Properties | Back Directory | [Appearance]
Colorless Liquid | [Boiling point ]
120 °C / 40mmHg | [density ]
1.04 | [refractive index ]
1.4270-1.4310 | [Fp ]
43°C(lit.) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [solubility ]
Chloroform, Methanol | [form ]
Oil | [color ]
Clear Colourless | [Stability:]
Moisture Sensitive | [InChIKey]
LTLKJYMNUSSFAH-UHFFFAOYSA-N | [CAS DataBase Reference]
29882-07-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
1993 | [HazardClass ]
3.2 | [PackingGroup ]
III | [HS Code ]
2909199090 |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless Liquid | [Uses]
4-Chlorobutanal Dimethyl Acetal 90% is a compound useful in organic synthesis and other chemical processes. It is used as an intermediate in the synthesis of aripiprazole, buspirone, and NAN-190 via reductive alkylation of piperazine derivatives with aldehydes | [Synthesis]
Preparation of 4-chlorobutanal dimethanol: 72 g (0.49 mol) of 4-chloro-1-acetoxy-1-butene was dissolved in 300 mL of anhydrous methanol, to which were added 240 g (7.5 mol) of methanol and 15 g of acidic ion exchange resin catalyst treated with macroporous resin 15. The mixture was stirred overnight under reflux conditions and the complete conversion of the E and Z isomers of 4-chloro-1-acetoxy-1-butene to a single high-boiling product, accompanied by a small number of side reactions, was confirmed by GC analysis. Upon completion of the reaction, the mixture was filtered to recover the catalyst and the filtrate was treated with 5 g of solid sodium bicarbonate. Excess methanol was removed by distillation under reduced pressure until the volume was reduced to about 50 mL. The liquid was decanted from the insoluble sodium bicarbonate and distilled through a 6-inch Vigro fractionating column at 25 mm Hg. A colorless fraction with a boiling range of 83-85 °C was collected to give 55.0 g of product (74.4% of the theoretical yield).NMR analysis confirmed the fraction as pure 4-chlorobutanal dimethyl acetal. | [References]
[1] Organic Preparations and Procedures International, 2004, vol. 36, # 5, p. 487 - 490
[2] Patent: US2004/192958, 2004, A1. Location in patent: Page 3 |
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