| Identification | More | [Name]
2,2-Dimethoxyethylamine | [CAS]
22483-09-6 | [Synonyms]
1-AMINO-2,2-DIMETHOXYETHANE
2,2-DIMETHOXYETHYLAMINE
2-AMINOACETALDEHYDE DIMETHYLACETAL
AMINOACETALDEHYDE DIMETHYL ACETAL
DEA
DIMETHYLAMINOACETAL
2,2-dimethoxy-ethanamin
2,2-Dimethoxyethanamine
Acetaldehyde, amino-, dimethyl acetal
Ethanamine, 2,2-dimethoxy-
2-Methoxy-N-[2-methoxyethyl]-1-ethaneamine
2-Aminoacetaldehyde dimethylacetal 98%
2,2-DIMETHYLETHANAMINE
β,β-diethoxy-N,N-dimethylethylamine
2,2-Dimethoxyethylamin
AMINOACETOLDEHYDE DIMETHYL ACETOL
2,2-Dimetoxyethyl Amine
Glycinal dimethyl acetal
Aminoacetaldehyde dimethyl acetal ,98% | [EINECS(EC#)]
245-026-5 | [Molecular Formula]
C4H11NO2 | [MDL Number]
MFCD00008135 | [Molecular Weight]
105.14 | [MOL File]
22483-09-6.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colorless to pale yellow liquid | [Melting point ]
-78°C | [Boiling point ]
135-139 °C/95 mmHg (lit.) | [density ]
0.965 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.417(lit.)
| [Fp ]
128 °F
| [storage temp. ]
Flammables area | [solubility ]
soluble in Chloroform, Methanol | [form ]
Liquid | [pka]
6.95±0.10(Predicted) | [color ]
Clear colorless to pale yellow | [Water Solubility ]
miscible | [Detection Methods]
GC | [BRN ]
741868 | [InChI]
1S/C4H11NO2/c1-6-4(3-5)7-2/h4H,3,5H2,1-2H3 | [InChIKey]
QKWWDTYDYOFRJL-UHFFFAOYSA-N | [SMILES]
COC(CN)OC | [CAS DataBase Reference]
22483-09-6(CAS DataBase Reference) | [NIST Chemistry Reference]
Aminoacetaldehyde dimethyl acetal(22483-09-6) | [EPA Substance Registry System]
22483-09-6(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS02,GHS05 | [Signal word ]
Danger | [Hazard statements ]
H226-H314 | [Precautionary statements ]
P210-P233-P240-P280-P303+P361+P353-P305+P351+P338 | [Hazard Codes ]
C,F,Xi | [Risk Statements ]
R10:Flammable.
R34:Causes burns.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S16:Keep away from sources of ignition-No smoking .
S36:Wear suitable protective clothing . | [RIDADR ]
UN 1993 3/PG 3
| [WGK Germany ]
2
| [Hazard Note ]
Flammable/Corrosive | [TSCA ]
Yes | [REACH Registrations]
Active | [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29225000 | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Flam. Liq. 3
Skin Corr. 1B |
| Hazard Information | Back Directory | [Description]
Aminoacetaldehyde dimethyl acetal, also known as 2,2-dimethoxy-ethylamine, is a critical intermediate in the synthesis of ivabradine hydrochloride, proline analogs, praziquantel, and other raw materials. The existing process for producing aminoacetal dimethyl acetate uses vinyl acetate as the starting material, and the target product is synthesized through bromination, Gabriel synthesis, and hydrazinolysis.
| [Chemical Properties]
clear colorless to pale yellow liquid | [Uses]
Amino acetaldehyde dimethyl was used in preparation of chitosan- dendrimer hybrids having various functional groups such as carboxyl, ester and poly(ethylene glycol). It was used in an synthesis of a bicyclic proline analog from L-ascorbic acid and in 3-component reaction catalyzed by MgClO4 leading to α-aminophosphonates. | [General Description]
Aminoacetaldehyde dimethyl acetal reacts with sulfone, followed by hydrolysis and reductive amination by adding desired piperazine derivative to yield piperazine derivatives of 2-furanyl[1,2,4]triazolo[1,5-a][1,3,5]triazine. | [Synthesis]
1)
to disposable in container, add the ammonia soln that
monochloroacetaldehyde dimethyl acetal and concentration are 10～40%,
stir;
2) by step 1) in reaction solution stir, this reaction solution is warming up to 100～150 ℃;
3) by step 2) in reaction solution distill, reclaim ammoniacal liquor, until steam without obvious cut;
4) in step 3) in reaction solution in to add concentration be 20%～50% aqueous sodium hydroxide solution, regulate pH to 12～14;
5)
by step 4) in solution carry out rectifying, collect colourless and
light yellow transparent liquid, be target product aminoacetaldehyde
dimethyl acetal. | [Purification Methods]
Dry the acetal over KOH pellets and distil it through a 30cm vacuum jacketed Vigreux column (p 11). [Lawson J Am Chem Soc 75 3398 1953, Erickson et al. J Am Chem Soc 77 6640 1955, Beilstein 4 IV 1918.] |
|
| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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