ChemicalBook--->CAS DataBase List--->299-95-6

299-95-6

299-95-6 Structure

299-95-6 Structure
IdentificationBack Directory
[Name]

Isoprenaline sulphate
[CAS]

299-95-6
[Synonyms]

aleudrin
Novodrin
Novodrine
medihaler-iso
ISOPRENALINE SULFATE
isoprenalinesulphate
ISOPROTERENOL SULFATE
ISO PROTERENOL SULPHATE
dl-Isoprenaline sulfate
dl-Isoproterenol sulfate
isoprenalinesulfate(2:1)
isoproterenolsulfate(2:1)
Isoprenaline Sulfate 
Isoprenaline sulfuric acid
Isoproterenol sulfuric acid
ISOPRENALINE HEMISULFATE SALT
(-)-ISOPROTERENOL HEMISULFATE
n-isopropylnorepinephrinesulfate
N-ISOPROPYLNORADRENALINE SULFATE
4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol
dl-a-3,4-Dihydroxyphenyl-b-iso-propylaminoethanol sulfate
1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol sulfate (2:1)
1-(3,4-DIHYDROXYPHENYL)-2-ISOPROPYLAMINOETHANOL HEMISULFATE SALT
3,4-dihydroxy-alpha-((isopropylamino)methyl)benzylalcoholsulfate(2:1)
2-benzenediol,4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-sulfate(2:1)
3,4-dihydroxy-alpha-((isopropylamino)methyl)-benzylalcohosulfate(2:1)(s
4-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]-1,2-benzenediol sulfate (2:1)
[EINECS(EC#)]

206-085-2
[Molecular Formula]

2C11H17NO3.H2O4S
[MDL Number]

MFCD00013139
[MOL File]

299-95-6.mol
[Molecular Weight]

520.6
Chemical PropertiesBack Directory
[Melting point ]

180 °C
[form ]

powder to crystal
[color ]

White to Almost white
[Water Solubility ]

almost transparency
Safety DataBack Directory
[Risk Statements ]

22
[Safety Statements ]

44
[RTECS ]

DO2273000
[HS Code ]

29072990
[Toxicity]

dog,LD50,intravenous,50mg/kg (50mg/kg),Drugs in Japan Vol. 6, Pg. 75, 1982.
Hazard InformationBack Directory
[Originator]

Isonorin,Smith, Miller and Patch,US,1949
[Uses]

Bronchodilator.
[Manufacturing Process]

As described in US Patent 2,308,232, 100 g 3,4-dihydroxy-ω- chloroacetophenone, 200 cc ethyl alcohol and 200 cc of about 50% aqueous isopropylamine solution are boiled during 3 hours on the water bath with the use of a reflux condenser, whereupon neutralizing with diluted sulfuric acid is carried out and the sulfate, obtained upon cooling, from alcohol of 50% is recrystallized; its MP is 245°C.
21 g 3,4-dihydroxy-ω-isopropylaminoacetophenone sulfate are hydrogenated with 50 cc methyl alcohol and 50 cc water, 0.5 g carbon and 3 cc palladium chloride solution of 2%. After 2 hours the hydrogen absorption comes to a standstill, after the theoretical quantity of hydrogen has been absorbed. After concentrating, the isopropylaminomethyl-(3,4-dihydroxyphenyl)carbinolsulfate crystallizes out. It has a MP of 180°C after refining.
[Brand name]

Medihaler-ISO (3M Pharmaceuticals).
[Therapeutic Function]

Bronchodilator
Spectrum DetailBack Directory
[Spectrum Detail]

Isoprenaline sulphate(299-95-6)1HNMR
Isoprenaline sulphate(299-95-6)IR1
Isoprenaline sulphate(299-95-6)IR2
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