| Identification | More | [Name]
Lofexidine | [CAS]
31036-80-3 | [Synonyms]
2-[1-(2,6-dichlorophenoxy)ethyl]-2-imidazoline
LOFEXIDINE
2-(1-(2,6-dichlorophenoxy)ethyl)-4,5-dihydro-1h-imidazol
2-(1-(2,6-dichlorophenoxy)ethyl)-4,5-dihydro-1h-imidazole
2-(alpha-(2,6-dichlorophenoxy)ethyl)2-imidazoline
6-dichlorophenoxy)ethyl)-2-imidazoline2-(1-(
LofexidineBase
Lofexidine Hcl 21498-08-8 /Base
2-[1-(2，6-Dichlomphenoxy)ethyl]-4，5-dihydro-1H-imidazole
1H-Imidazole, 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-
MDL-14042 | [Molecular Formula]
C11H12Cl2N2O | [MDL Number]
MFCD00865915 | [Molecular Weight]
259.13 | [MOL File]
31036-80-3.mol |
| Chemical Properties | Back Directory | [Melting point ]
126-128° | [Boiling point ]
421.5±35.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
DMSO: 62.5 mg/mL (241.19 mM) | [form ]
Solid | [pka]
9.80±0.40(Predicted) | [color ]
White to off-white | [CAS DataBase Reference]
31036-80-3(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Crystallized, melting point 126-128°C. Lofexidine Hydrochloride: C????H????(Cl??N??O)HCl. [21498-08-8]. Crystallized from ethanol-ether or 2-propanol, melting point 221-223°C; also found to have a melting point of 230-232°C. Highly soluble in water and ethanol, slightly soluble in 2-propanol, and practically insoluble in ether. Acute toxicity LD50 in mice, rats, and dogs (mg/kg): 74-147 mg/kg orally; 8-18 mg/kg intravenously. | [Uses]
An tihypertensive. | [Definition]
ChEBI: Lofexidine is a member of imidazoles, a dichlorobenzene, an aromatic ether and a carboxamidine. It has a role as an alpha-adrenergic agonist and an antihypertensive agent. | [Brand name]
Lofexidine (Rhone-Poulenc Rorer). | [storage]
Store at -20°C |
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