| Identification | More | [Name]
4-Chloro-7-(trifluoromethyl)quinoline | [CAS]
346-55-4 | [Synonyms]
4-CHLORO-7-(TRIFLUOROMETHYL)QUINOLINE
BUTTPARK 15\09-27
Quinoline, 4-chloro-7-(trifluoromethyl)-
4-CHLORO-7-(TRIFLUOROMETHYL)QUINOLINE, 9 8%
4-Chloro-7-(trifluoromethyl)quinoline 98% | [EINECS(EC#)]
206-471-0 | [Molecular Formula]
C10H5ClF3N | [MDL Number]
MFCD00006775 | [Molecular Weight]
231.6 | [MOL File]
346-55-4.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal powder | [Melting point ]
69-71 °C(lit.) | [Boiling point ]
265.5±35.0 °C(Predicted) | [density ]
1.4120 (estimate) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [solubility ]
chloroform: soluble25mg/mL, clear, colorless | [form ]
Solid | [pka]
1.18±0.27(Predicted) | [color ]
Light Beige to Beige | [InChI]
1S/C10H5ClF3N/c11-8-3-4-15-9-5-6(10(12,13)14)1-2-7(8)9/h1-5H | [InChIKey]
LLRQVSZVVAKRJA-UHFFFAOYSA-N | [SMILES]
FC(F)(F)c1ccc2c(Cl)ccnc2c1 | [CAS DataBase Reference]
346-55-4(CAS DataBase Reference) | [NIST Chemistry Reference]
4-Chloro-7-(trifluoromethyl)quinoline(346-55-4) |
| Questions And Answer | Back Directory | [Synthesis]
Starting with readily available 3-trifluoromethoxynitrobenzene, the target product 4-chloro-7-trifluoromethylquinoline was obtained through a six-step reaction involving O-alkylation, reduction, high-temperature cyclization, hydrolysis, decarboxylation, and chlorination. The synthetic reaction formula is shown in the figure below: 
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| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
2933499090 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystal powder | [Uses]
4-Chloro-7-(trifluoromethyl)quinoline is a reagent in the preparation of piperazinylquinolines as breast cancer inhibitors. |
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| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Tetranov Biopharm
|
| Telephone: |
13526569071 |
| Website: |
http://www.leadmedpharm.com/index.html |
| Company Name: |
Shanghai Ennopharm Co., Ltd.
|
| Telephone: |
+86 (21) 6435-5022 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList13640/0_EN.htm |
|