| Identification | More | [Name]
1,3-Dimethyl-1H-pyrazol-5-amine | [CAS]
3524-32-1 | [Synonyms]
1,3-DIMETHYL-1H-PYRAZOL-5-AMINE
2,5-DIMETHYL-2H-PYRAZOL-3-YLAMINE
3-AMINO-2,5-DIMETHYL-2H-PYRAZOLE
5-AMINO-1,3-DIMETHYLPYRAZOLE
AKOS B024294
AKOS BBS-00004675
AKOS PAO-1219
ART-CHEM-BB B024294
BUTTPARK 29\04-74
1,3-Dimethyl-1H-pyrazol-5-ylamine
1,3-Dimethyl-5-amino-pyrazole
5-Amino-1,3-dimethyl-1H-pyrazole
1,3-Dimethyl-1H-pyrazole-5-amine ,97% | [EINECS(EC#)]
2017-001-1 | [Molecular Formula]
C5H9N3 | [MDL Number]
MFCD00051651 | [Molecular Weight]
111.15 | [MOL File]
3524-32-1.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal powde | [Melting point ]
65-69 °C (lit.) | [Boiling point ]
121-123 °C(Press: 9 Torr) | [density ]
1.17±0.1 g/cm3(Predicted) | [Fp ]
88 °C | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
crystalline powder | [pka]
4?+-.0.10(Predicted) | [color ]
Light orange | [Sensitive ]
Hygroscopic | [Detection Methods]
HPLC | [BRN ]
113420 | [InChI]
InChI=1S/C5H9N3/c1-4-3-5(6)8(2)7-4/h3H,6H2,1-2H3 | [InChIKey]
ZFDGMMZLXSFNFU-UHFFFAOYSA-N | [SMILES]
N1(C)C(N)=CC(C)=N1 | [CAS DataBase Reference]
3524-32-1(CAS DataBase Reference) | [NIST Chemistry Reference]
5-Amino-1,3-dimethylpyrazole(3524-32-1) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R22:Harmful if swallowed. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [HS Code ]
29331990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystal powde | [Uses]
5-Amino-1,3-dimethylpyrazole may be used in the preparation of:
- 5-benzamido-1,3-dimethylpyrazole
- diethyl 2-{[(1,3-dimethyl-1H-pyrazol-5-yl)amino]methylene}malonate
- 5-amino-1,3-dimethyl-4-phthalidylpyrazole
- (E)-N-(3,7-dimethylocta-2,6-dienyl)-1,3-dimethyl-1H-pyrazol-5-amine analog(LQFM002)
- 4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-ol
| [General Description]
5-Amino-1,3-dimethylpyrazole undergoes cyclocondensation with ethyl acetoacetate to form the corresponding tetrahydropyrazolopyridine derivatives. | [Synthesis]
To a solution of 3-aminobut-2-enenenitrile (16.5 g, 0.2 mol) in n-pentanol (40 mL) was slowly added methylhydrazine (12.9 g, 0.28 mol). The reaction mixture was heated to reflux and kept for 3 hours. Upon completion of the reaction, n-pentanol and excess methylhydrazine were removed by distillation under reduced pressure. The resulting beige precipitate was dissolved in heptane (150 mL) and filtered through a sintered funnel. The filtrate was dried under vacuum at 40 °C to afford 5-amino-1,3-dimethylpyrazole as a beige solid (13.5 g, 60.4% yield). | [References]
[1] Patent: WO2012/92880, 2012, A1. Location in patent: Page/Page column 59
[2] Journal of the American Chemical Society, 1959, vol. 81, p. 2452,2455
[3] Patent: US6338741, 2002, B1. Location in patent: Page column 15
[4] Journal of Combinatorial Chemistry, 2010, vol. 12, # 4, p. 510 - 517 |
|
|